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Case Reports
. 2023 Jun 20:20:100377.
doi: 10.1016/j.lrr.2023.100377. eCollection 2023.

Membranous nephropathy in chronic lymphocytic leukemia responsive to ibrutinib: A case report

Anna-Eve Turcotte  1 , William F Glass  2   3 , Jamie S Lin  1 , Jan A Burger  4
Affiliations
Case Reports

Membranous nephropathy in chronic lymphocytic leukemia responsive to ibrutinib: A case report

Anna-Eve Turcotte et al. Leuk Res Rep. .

Abstract

Membranous nephropathy (MN) is an uncommon renal presentation in patients with chronic lymphocytic leukemia (CLL), and as such, there is no standard therapy for these patients. A few cases of MN in CLL have been described with varying success in MN treatment involving alkylating agents and fludarabine. Here we report the first case of MN in a patient with CLL treated with ibrutinib with complete renal response. This presentation underlines the importance of recognizing rare glomerular diseases that may occur with CLL and offers a new therapeutic avenue to the treatment of CLL-associated MN.

Keywords: Bruton tyrosine kinase; Case report; Chronic lymphocytic leukemia; Membranous nephropathy; Paraneoplastic.

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Conflict of interest statement

The authors have declared that no conflict of interest exists.

Figures

Fig 1
Fig. 1
Renal histology. (A) Periodic acid-Schiff (PAS) stain shows mild to moderate mesangial matrix expansion and thick glomerular basement membranes. (B) Jones silver stain demonstrating basement membrane spikes. (C) Immunofluorescence staining reveals diffuse granular immunoglobulin G (IgG) capillary wall deposits and (D) C3 capillary deposits. (E) Electron micrograph images show numerous subepithelial electron dense deposits with expansion of glomerular basement membranes and (F) expansion of mesangial matrix with abundant mesangial deposits.
See this image and copyright information in PMC

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