Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2023 Sep;128(9):1061-1069.
doi: 10.1007/s11547-023-01672-z. Epub 2023 Jul 17.

Microwave ablation with a blunt-tip antenna for pulmonary ground-glass nodules: a retrospective, multicenter, case-control study

Zhigang Wei #  1   2 , Jiachang Chi #  3 , Pikun Cao #  1 , Yong Jin  4 , Xiaoguang Li  5 , Xin Ye  6
Affiliations
Multicenter Study

Microwave ablation with a blunt-tip antenna for pulmonary ground-glass nodules: a retrospective, multicenter, case-control study

Zhigang Wei et al. Radiol Med. 2023 Sep.

Abstract

Purpose: A previous small-sample study verified that a blunt-tip antenna reduced hemorrhage during microwave ablation. We conducted this large-sample, multicenter, case-control study to further verify the efficacy and safety of microwave ablation with a blunt-tip antenna for ground-glass nodules.

Materials and methods: Patients with pulmonary ground-glass nodules were treated with either a sharp-tip (Group A) or blunt-tip antenna (Group B). A total of 147 and 150 patients were retrospectively allocated to Groups A and Group B, respectively. Group A patients underwent 151 procedures, and Group B patients underwent 153 procedures. We assessed the technical success, technique efficacy, and complications.

Results: Technical success and overall technique efficacy were achieved in all patients (100%). Major complications of pneumothorax were more commonly observed in Group A than in Group B (19.7% vs. 2.0%, p < 0.001). Minor complications, such as intrapulmonary hemorrhage (2.0% vs. 9.5%, p = 0.005) and hemothorax (0.0% vs. 2.7%, p = 0.049), occurred less frequently in Group B compared to Group A.

Conclusion: In the treatment of ground-glass nodules, microwave ablation with a blunt-tip antenna had equal efficacy compared to microwave ablation with a sharp-tip antenna but had a decreased number of hemorrhage and hemothorax complications.

Keywords: Blunt-tip antenna; Ground-glass nodules; Microwave ablation; Non-small cell lung cancer.

PubMed Disclaimer

Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Model of a blunt-tip antenna. A Antenna with a blunt-tip; B the details of the blunt-tip; C a coordinating trocar
Fig. 2
Fig. 2
A 48-year-old female patient with pathologically verified MIA underwent ablation with a blunt-tip antenna. A A mixed GGN located in the left lower lobe before ablation; B a blunt-tip was inserted into the GGN lesion; C the GGN lesion decreased 3 months post-ablation; D the GGN lesion decreased in advance 12 months post-ablation; E the GGN lesion disappeared 24 months post-ablation
Fig. 3
Fig. 3
A 58-year-old male patient with pathologically verified MIA underwent ablation with a blunt-tip antenna. A A mixed GGN located in the right lower lobe before ablation; B a blunt-tip was inserted into the GGN lesion; C pneumothorax was observed when ablation procedure was finished; D the GGN lesion enlarged 3 months post-ablation; E the GGN lesion disappeared 6 months post-ablation
See this image and copyright information in PMC

References

    1. Xia C, Dong X, Li H, Cao M, Sun D, He S, et al. Cancer Statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J. 2022;135:584–590. doi: 10.1097/CM9.0000000000002108. - DOI - PMC - PubMed
    1. Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83:584–594. doi: 10.4065/83.5.584.PMID:18452692;PMCID:PMC2718421. - DOI - PMC - PubMed
    1. Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, et al. The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 2016;11:39–51. doi: 10.1016/j.jtho.2015.09.009. - DOI - PubMed
    1. National Lung Screening Trial Research Team. Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395–409. doi: 10.1056/NEJMoa1102873. - DOI - PMC - PubMed
    1. de Koning HJ, van der Aalst CM, de Jong PA, Scholten ET, Nackaerts K, Heuvelmans MA, et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med. 2020;382:503–513. doi: 10.1056/NEJMoa1911793. - DOI - PubMed

Publication types

LinkOut - more resources