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. 2023 Jul 17;13(7):e072367.
doi: 10.1136/bmjopen-2023-072367.

Is personalised prehabilitation feasible to implement for patients undergoing oncological treatment for lung cancer at a London teaching hospital? Protocol of a feasibility trial

Kelly Wade-Mcbane  1 , Alex King  2 , Catherine Urch  2 , Lina Johansson  3 , Mary Wells  4
Affiliations

Is personalised prehabilitation feasible to implement for patients undergoing oncological treatment for lung cancer at a London teaching hospital? Protocol of a feasibility trial

Kelly Wade-Mcbane et al. BMJ Open. .

Abstract

Introduction: There is significant potential to improve outcomes for patients with lung cancer in terms of quality of life and survival. There is some evidence that prehabilitation can help, but, to date, this has only been tested in surgical populations, despite 70%-80% of patients with lung cancer in the UK receiving non-surgical treatment. The physiological and psychological benefits of prehabilitation seen in surgical patients could be extrapolated to those receiving non-surgical treatment, particularly in such a poor prognosis group. With patients and healthcare professionals, we have co-designed a personalised and evidence-based prehabilitation programme. This draws on a conceptual framework that aligns with patient values and needs as well as functional goals. We aim to investigate whether this programme is feasible to implement and evaluate in clinical practice.

Methods and analysis: An open-label, single-group feasibility study incorporating quantitative assessments, a qualitative free text questionnaire and reflective field notes. Thirty participants will be recruited over an eight-month period from a single London teaching hospital. All recruited participants will receive a personalised prehabilitation programme during their oncological treatment. This includes a one-hour face-to-face appointment prior to, at week three and at week six of their treatment regimen as well as a weekly telephone call. Interventions including nutrition, physical activity and psychological well-being are stratified according to a patient's priorities, level of readiness and expressed needs. The primary outcome will be feasibility of the personalised prehabilitation programme in clinical practice by investigating areas of uncertainty regarding patient recruitment, attrition, treatment fidelity, intervention adherence and acceptability of study outcome measures. Secondary outcomes will include quality of life, functional capacity and grip strength.

Ethics and dissemination: Ethical approval has been obtained from the Health Research Authority (reference number 22/PR/0390). Results of this study will be disseminated through publication in peer-reviewed articles, presentations at scientific conferences and in collaboration with patient and public involvement representatives.

Trial registration number: NCT05318807.

Keywords: chemotherapy; radiotherapy; respiratory tract tumours.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Diagrammatic representation of the Adversity, Restoration and Compatibility (ARC) model of the experience of adjusting to living with and beyond cancer. The waves and curves reflect the fluidity and non-linear nature of the process, with the sizes reducing as one adjusts to living with and beyond cancer.
Figure 2
Figure 2
(A–C) Examples of the models used in the personalised prehabilitation programme for psychological well-being, nutrition and physical activity.
See this image and copyright information in PMC

References

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