Update of recommendations for the management of COVID-19 in patients with haematological malignancies, haematopoietic cell transplantation and CAR T therapy, from the 2022 European Conference on Infections in Leukaemia (ECIL 9)

Simone Cesaro^#¹, Malgorzata Mikulska^#^{2

3}, Hans H Hirsch^{4

5

6}, Jan Styczynski⁷, Sylvain Meylan⁸, Catherine Cordonnier⁹, Davide Navarro^{10

11

12}, Marie von Lilienfeld-Toal^{13

14}, Varun Mehra¹⁵, Francesco Marchesi¹⁶, Caroline Besson¹⁷, Raul Cordoba Masculano¹⁸, Gernot Beutel¹⁹, Herman Einsele²⁰, Johan Maertens²¹, Rafael de la Camara²²; ECIL 9; Per Ljungman^#^{23

24}, Livio Pagano^#²⁵

Collaborators, Affiliations

Collaborators

ECIL 9:
Marie von Lilienfeld-Toal, Rafael de la Camara

Affiliations

¹ Paediatric Haematology-Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy. simone.cesaro@aovr.veneto.it.
² Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.
³ IRCCS Ospedale Policlinico San Martino, Genova, Italy.
⁴ Transplantation & Clinical Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁵ Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
⁶ Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
⁷ Department of Paediatric Haematology and Oncology, Jurasz University Hospital, Nicolaus Copernicus University Torun, Collegium Medicum, Bydgoszcz, Poland.
⁸ Infectious Diseases Service, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
⁹ Haematology Department, Henri Mondor Hospital, APHP, and University Paris Est-Créteil, Paris, France.
¹⁰ Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
¹¹ CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
¹² Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.
¹³ Klinik fur Innere Medizin II (Haematologie/Oncologie), Universitatsklinikum Jena, Jena, Germany.
¹⁴ Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.
¹⁵ Department of Haematology, King's College Hospital NHS Foundation Trust, London, United Kingdom.
¹⁶ Haematology Unit, Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
¹⁷ Service d'Hematologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, Villejuif, France.
¹⁸ Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
¹⁹ Department for Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
²⁰ Department of Internal Medicine II, University of Würzburg, Würzburg, Germany.
²¹ Haematology Department, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
²² Department of Haematology, Hospital de la Princesa, Madrid, Spain.
²³ Division of Haematology, Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden.
²⁴ Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
²⁵ Institute of Haematology, Faculty of Medicine and Surgery, "Sacro Cuore" Catholic University, Rome, Italy.

^# Contributed equally.

PMID: 37460673
PMCID: PMC10457191
DOI: 10.1038/s41375-023-01938-5

Update of recommendations for the management of COVID-19 in patients with haematological malignancies, haematopoietic cell transplantation and CAR T therapy, from the 2022 European Conference on Infections in Leukaemia (ECIL 9)

Simone Cesaro et al. Leukemia. 2023 Sep.

. 2023 Sep;37(9):1933-1938.

doi: 10.1038/s41375-023-01938-5. Epub 2023 Jul 17.

Authors

Collaborators

ECIL 9:
Marie von Lilienfeld-Toal, Rafael de la Camara

Affiliations

¹ Paediatric Haematology-Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, Verona, Italy. simone.cesaro@aovr.veneto.it.
² Division of Infectious Diseases, Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.
³ IRCCS Ospedale Policlinico San Martino, Genova, Italy.
⁴ Transplantation & Clinical Virology, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁵ Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
⁶ Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.
⁷ Department of Paediatric Haematology and Oncology, Jurasz University Hospital, Nicolaus Copernicus University Torun, Collegium Medicum, Bydgoszcz, Poland.
⁸ Infectious Diseases Service, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
⁹ Haematology Department, Henri Mondor Hospital, APHP, and University Paris Est-Créteil, Paris, France.
¹⁰ Microbiology Service, Clinic University Hospital, INCLIVA Health Research Institute, Valencia, Spain.
¹¹ CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.
¹² Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain.
¹³ Klinik fur Innere Medizin II (Haematologie/Oncologie), Universitatsklinikum Jena, Jena, Germany.
¹⁴ Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany.
¹⁵ Department of Haematology, King's College Hospital NHS Foundation Trust, London, United Kingdom.
¹⁶ Haematology Unit, Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
¹⁷ Service d'Hematologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, Villejuif, France.
¹⁸ Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
¹⁹ Department for Haematology, Haemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.
²⁰ Department of Internal Medicine II, University of Würzburg, Würzburg, Germany.
²¹ Haematology Department, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
²² Department of Haematology, Hospital de la Princesa, Madrid, Spain.
²³ Division of Haematology, Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden.
²⁴ Department of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska Comprehensive Cancer Center, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
²⁵ Institute of Haematology, Faculty of Medicine and Surgery, "Sacro Cuore" Catholic University, Rome, Italy.

^# Contributed equally.

PMID: 37460673
PMCID: PMC10457191
DOI: 10.1038/s41375-023-01938-5

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

References

1. Cesaro S, Ljungman P, Mikulska M, Hirsch HH, von Lilienfeld-Toal M, Cordonnier C, et al. Recommendations for the management of COVID-19 in patients with haematological malignancies or haematopoietic cell transplantation, from the 2021 European Conference on Infections in Leukaemia (ECIL 9). Leukemia. 2022. 10.1038/s41375-022-01578-1. - PMC - PubMed
1. Pagano L, Salmanton-García J, Marchesi F, Blennow O, Gomes da Silva M, Glenthøj A, et al. Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey. Blood. 2022;140:2773–87. doi: 10.1182/blood.2022017257. - DOI - PMC - PubMed
1. Leuzinger K, Roloff T, Egli A, Hirsch HH. Impact of SARS-CoV-2 omicron on rapid antigen testing developed for early-pandemic SARS-CoV-2 variants. Microbiol Spectr. 2022;10:e0200622. doi: 10.1128/spectrum.02006-22. - DOI - PMC - PubMed
1. Martin-Vicente M, Almansa R, Martínez I, Tedim AP, Bustamante E, Tamayo L, et al. Low anti-SARS-CoV-2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID-19 patients. J Intern Med. 2022;291:232–40. doi: 10.1111/joim.13386. - DOI - PMC - PubMed
1. Misra A, Theel ES. Immunity to SARS-CoV-2: what do we know and should we be testing for it? J Clin Microbiol. 2022;60:e0048221. doi: 10.1128/jcm.00482-21. - DOI - PMC - PubMed

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Update of recommendations for the management of COVID-19 in patients with haematological malignancies, haematopoietic cell transplantation and CAR T therapy, from the 2022 European Conference on Infections in Leukaemia (ECIL 9)

Collaborators

Affiliations

Update of recommendations for the management of COVID-19 in patients with haematological malignancies, haematopoietic cell transplantation and CAR T therapy, from the 2022 European Conference on Infections in Leukaemia (ECIL 9)

Authors

Collaborators

Affiliations

Conflict of interest statement

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical