SGLT2 Inhibitors as the Backbone of Therapy for Cardiovascular and Renal Protection

Felice Gragnano^{1

2}, Fabrizia Terracciano^{3

4}, Paolo Calabrò^{3

4}

Affiliations

¹ Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Viale Abramo Lincoln 5, IT-81100, Caserta, Italy. felice.gragnano@unicampania.it.
² Division of Clinical Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", F. Palasciano, IT-81100, Caserta, Italy. felice.gragnano@unicampania.it.
³ Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Viale Abramo Lincoln 5, IT-81100, Caserta, Italy.
⁴ Division of Clinical Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", F. Palasciano, IT-81100, Caserta, Italy.

Editorial

Felice Gragnano et al. J Cardiovasc Transl Res. 2024 Feb.

. 2024 Feb;17(1):227-229.

doi: 10.1007/s12265-023-10415-4. Epub 2023 Jul 17.

Felice Gragnano^{1

2}, Fabrizia Terracciano^{3

4}, Paolo Calabrò^{3

4}

¹ Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Viale Abramo Lincoln 5, IT-81100, Caserta, Italy. felice.gragnano@unicampania.it.
² Division of Clinical Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", F. Palasciano, IT-81100, Caserta, Italy. felice.gragnano@unicampania.it.
³ Department of Translational Medical Sciences, University of Campania "Luigi Vanvitelli", Viale Abramo Lincoln 5, IT-81100, Caserta, Italy.
⁴ Division of Clinical Cardiology, A.O.R.N. "Sant'Anna e San Sebastiano", F. Palasciano, IT-81100, Caserta, Italy.

No abstract available

References

1. van der Aart-van der Beek AB, de Boer RA, Heerspink HJL. Kidney and heart failure outcomes associated with SGLT2 inhibitor use. Nat Rev Nephrol. 2022;18(5):294–306. https://doi.org/10.1038/s41581-022-00535-6 . - DOI - PubMed
1. Palmiero G, Cesaro A, Vetrano E, Pafundi PC, Galiero R, Caturano A, et al. Impact of SGLT2 inhibitors on heart failure: from pathophysiology to clinical effects. Int J Mol Sci. 2021;22(11):5863. https://doi.org/10.3390/ijms22115863 . - DOI - PubMed - PMC
1. Mustapic I, Bakovic D, Susilovic-Grabovac Z, Borovac JA. Left ventricular systolic function after 3 months of SGLT2 inhibitor therapy in heart failure patients with reduced ejection fraction. J Cardiovasc Transl Res. 2023;1–12. https://doi.org/10.1007/s12265-023-10389-3 .
1. Usman MS, Siddiqi TJ, Anker SD, Bakris GL, Bhatt DL, Filippatos G, et al. Effect of SGLT2 inhibitors on cardiovascular outcomes across various patient populations. J Am Coll Cardiol. 2023;81(25):2377–87. https://doi.org/10.1016/j.jacc.2023.04.034 . - DOI - PubMed
1. Paolisso P, Bergamaschi L, Gragnano F, Gallinoro E, Cesaro A, Sardu C, et al. Outcomes in diabetic patients treated with SGLT2-inhibitors with acute myocardial infarction undergoing PCI: The SGLT2-I AMI PROTECT Registry. Pharmacol Res. 2023;187:106597. https://doi.org/10.1016/j.phrs.2022.106597 . - DOI - PubMed