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Review
. 2023 Jul 17;43(1):38.
doi: 10.1186/s41232-023-00289-z.

Lipid in microglial biology - from material to mediator

Shota Yamamoto  1 , Takahiro Masuda  2
Affiliations
Review

Lipid in microglial biology - from material to mediator

Shota Yamamoto et al. Inflamm Regen. .

Abstract

Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as a crucial mechanism for diversification of microglial functionality. Lipids are highly diverse materials and crucial components of cell membranes in every cell. Accumulating evidence has shown that lipid and its metabolism are tightly involved in microglial biology. In this review, we summarize the current knowledge about microglial lipid metabolism in health and disease.

Keywords: CNS; Lipid; Macrophage; Microglia.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Lipidomic alterations of microglia between healthy and disease conditions. During disease and inflammation, microglial lipidome is drastically changed, which includes upregulation of lipid-related gene expressions (Abca1, Apoe, Cd36, Lpl, and others), accumulation of lipid droplet, compositional remodeling of membrane phospholipids, and followed by conformational changes of membrane proteins
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