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[Preprint]. 2023 Jun 26:rs.3.rs-3084887.
doi: 10.21203/rs.3.rs-3084887/v1.

Clinical impact of timing of surgery on outcomes in preterm infants with surgical necrotizing enterocolitis

Parvesh Mohan Garg  1 , Robin Riddick  2 , Md Abu Yusuf Ansari  2 , Isabella Pittman  2 , William Hillegass  2
Affiliations

Clinical impact of timing of surgery on outcomes in preterm infants with surgical necrotizing enterocolitis

Parvesh Mohan Garg et al. Res Sq. .

Update in

Abstract

Background: The clinical impact of the timing of surgery on outcomes in preterm infants with surgical necrotizing enterocolitis (NEC) is not well defined.

Aim: We sought to investigate the impact of the different timing of surgery from the day of NEC diagnosis on clinical outcomes in preterm infants with surgical NEC.

Study design: Retrospective Cohort Study.

Subjects: Preterm 75 infants admitted between January 2013 and December 31, 2018, with an NEC (Bell stage III) diagnosis.

Outcomes: Comparison of clinical information by the timing of surgery at three different time points (less and more than 48 hours, 96 hours, and 168 hours) in preterm infants with surgical NEC.

Results: 75 infants were included in the analysis. Those who received surgery after 48 hours (n= 29/75) had lower median gestational age, lower birth weight, had less pneumoperitoneum, were out born less frequently, had higher acute kidney injury, were intubated and ventilated more frequently, and had higher hemorrhagic and reparative lesions on histopathology than those receiving surgery after 48 hours. Infants receiving surgery after 96 hours had similar trends expect had significantly lower hematocrit and more prolonged parenteral nutrition dependence than less than 96 hours group. The infants receiving surgery after one week had significantly lower birth weight and had higher reparative changes and cholestasis than those receiving surgery < 1 week.There was no significant impact of surgery timing on the length of bowel loss, surgical morbidity, Bronchopulmonary dysplasia, white matter injury, and mortality.

Conclusion: The infants receiving surgery later were young and smaller and received parenteral nutrition longer with no significant impact on morbidities and mortality. Our data point out that there are advantages of operating early with fewer morbidities which need further confirmation and evaluation in large multicentric prospective studies or clinical trials.

Keywords: Laparotomy; Neonate; Outcomes; Penrose Drain; Preterm infants; Surgical Necrotizing Enterocolitis; Timing of disease onset.

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Conflict of interest statement

Conflicts of interest: The authors disclose no conflicts.

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