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[Preprint]. 2023 Jun 30:rs.3.rs-3069713.

doi: 10.21203/rs.3.rs-3069713/v1.

[WITHDRAWN] Activation of transsulfuration pathway to maintain cysteine is a thermogenic checkpoint for the conservation of energy

Aileen H Lee^{1

2

3}, Yuki Sugiura⁴, Yun-Hee Youm^{1

2

3}, Tamara Dlugos^{1

2

3}, Rae Maeda⁴, Daniel Coman^{5

6}, Olga Spadaro^{1

2

3}, Sviatoslav Sidorov^{1

2

3}, Irina Shchukina⁷, Sairam Andhey⁷, Steven R Smith⁸, Eric Ravussin⁹, Fahmeed Hyder^{5

6}, Maxim N Artyomov⁷, Vishwa Deep Dixit^{1

2

3

10}

Affiliations

¹ Department of Pathology.
² Department of Comparative Medicine.
³ Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
⁴ University of Kyoto, Japan.
⁵ Department of Radiology and Biomedical Imaging.
⁶ Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University.
⁷ Department of Pathology and Immunology Washington University School of Medicine, St. Louis, MO 63110, USA.
⁸ Translational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, FL, USA.
⁹ Pennington Biomedical Research Center, Baton Rouge, LA, USA.
¹⁰ Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520, USA.

PMID: 37461682
PMCID: PMC10350108
DOI: 10.21203/rs.3.rs-3069713/v1

[WITHDRAWN] Activation of transsulfuration pathway to maintain cysteine is a thermogenic checkpoint for the conservation of energy

Aileen H Lee et al. Res Sq. 2023.

[Preprint]. 2023 Jun 30:rs.3.rs-3069713.

doi: 10.21203/rs.3.rs-3069713/v1.

Authors

Affiliations

¹ Department of Pathology.
² Department of Comparative Medicine.
³ Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
⁴ University of Kyoto, Japan.
⁵ Department of Radiology and Biomedical Imaging.
⁶ Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University.
⁷ Department of Pathology and Immunology Washington University School of Medicine, St. Louis, MO 63110, USA.
⁸ Translational Research Institute for Metabolism and Diabetes, AdventHealth, Orlando, FL, USA.
⁹ Pennington Biomedical Research Center, Baton Rouge, LA, USA.
¹⁰ Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520, USA.

PMID: 37461682
PMCID: PMC10350108
DOI: 10.21203/rs.3.rs-3069713/v1

Update in

Cysteine depletion triggers adipose tissue thermogenesis and weight loss.
Lee AH, Orliaguet L, Youm YH, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey PS, Smith SR, Ravussin E, Stadler K, Chen B, Artyomov MN, Hyder F, Horvath TL, Schneeberger M, Sugiura Y, Dixit VD. Lee AH, et al. Nat Metab. 2025 Jun;7(6):1204-1222. doi: 10.1038/s42255-025-01297-8. Epub 2025 Jun 3. Nat Metab. 2025. PMID: 40461845 Free PMC article.

Abstract

The authors have requested that this preprint be removed from Research Square.

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This is a preprint.

[WITHDRAWN] Activation of transsulfuration pathway to maintain cysteine is a thermogenic checkpoint for the conservation of energy

Affiliations

[WITHDRAWN] Activation of transsulfuration pathway to maintain cysteine is a thermogenic checkpoint for the conservation of energy

Authors

Affiliations

Update in

Abstract

Publication types

LinkOut - more resources

Full Text Sources