Ferritin as an iron-storage protein: mechanisms of iron uptake
- PMID: 3746295
- DOI: 10.1016/0162-0134(86)80068-x
Ferritin as an iron-storage protein: mechanisms of iron uptake
Abstract
The major physiological role of the ubiquitous protein ferritin is to store iron, which it does as a mineral core within a protein shell. Using evidence from a variety of sources we suggest that this versatile protein responds in its mechanism of iron uptake to changes in environmental conditions.
Similar articles
-
Ferritin: molecular structure and iron-storage mechanisms.Prog Biophys Mol Biol. 1980;36(2-3):56-86. Prog Biophys Mol Biol. 1980. PMID: 7008081 Review. No abstract available.
-
Ferritin: design and formation of an iron-storage molecule.Philos Trans R Soc Lond B Biol Sci. 1984 Feb 13;304(1121):551-65. doi: 10.1098/rstb.1984.0046. Philos Trans R Soc Lond B Biol Sci. 1984. PMID: 6142491
-
The ferritins: molecular properties, iron storage function and cellular regulation.Biochim Biophys Acta. 1996 Jul 31;1275(3):161-203. doi: 10.1016/0005-2728(96)00022-9. Biochim Biophys Acta. 1996. PMID: 8695634 Review.
-
Mechanism of ferritin iron uptake: activity of the H-chain and deletion mapping of the ferro-oxidase site. A study of iron uptake and ferro-oxidase activity of human liver, recombinant H-chain ferritins, and of two H-chain deletion mutants.J Biol Chem. 1988 Dec 5;263(34):18086-92. J Biol Chem. 1988. PMID: 3192527
-
The iron redox and hydrolysis chemistry of the ferritins.Biochim Biophys Acta. 2010 Aug;1800(8):719-31. doi: 10.1016/j.bbagen.2010.03.021. Epub 2010 Apr 9. Biochim Biophys Acta. 2010. PMID: 20382203 Review.
Cited by
-
Ferritin microheterogeneity, subunit composition, functional, and physiological implications.Sci Rep. 2023 Nov 14;13(1):19862. doi: 10.1038/s41598-023-46880-9. Sci Rep. 2023. PMID: 37963965 Free PMC article.
-
Evidence of H- and L-chains have co-operative roles in the iron-uptake mechanism of human ferritin.Biochem J. 1992 Dec 1;288 ( Pt 2)(Pt 2):591-6. doi: 10.1042/bj2880591. Biochem J. 1992. PMID: 1463463 Free PMC article.
-
Defining the roles of the threefold channels in iron uptake, iron oxidation and iron-core formation in ferritin: a study aided by site-directed mutagenesis.Biochem J. 1993 Dec 15;296 ( Pt 3)(Pt 3):721-8. doi: 10.1042/bj2960721. Biochem J. 1993. PMID: 7506527 Free PMC article.
-
Purification, electrophoretic behavior, and kinetics of iron release of liver ferritin of Dasyatis akajei.J Protein Chem. 2003 Jan;22(1):61-70. doi: 10.1023/a:1023019911749. J Protein Chem. 2003. PMID: 12739899
-
Molecular diffusion into ferritin: pathways, temperature dependence, incubation time, and concentration effects.Biophys J. 2000 Apr;78(4):2049-59. doi: 10.1016/S0006-3495(00)76752-X. Biophys J. 2000. PMID: 10733983 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical