Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study

Daniele De Luca^{1

2}, Elizabeth Perkins^{3

4}, David G Tingay^{3

4}; European Society of Pediatric and Neonatal Intensive Care COVID-19 Paediatric and Neonatal Registry Group; European society of pediatric and neonatal intensive care covid-19 paediatric and neonatal registry (EPICENTRE) group - group authorship; European Society of Pediatric and Neonatal Intensive Care COVID-19 Paediatric and Neonatal Registry Group and European society of pediatric and neonatal intensive care covid-19 paediatric and neonatal registry (EPICENTRE) group - group authorship

Collaborators, Affiliations

Collaborators

European Society of Pediatric and Neonatal Intensive Care COVID-19 Paediatric and Neonatal Registry Group and European society of pediatric and neonatal intensive care covid-19 paediatric and neonatal registry (EPICENTRE) group - group authorship:
Danilo Buonsenso⁵, Roberta Centorrino, Alexandre Vivanti⁶, Shancy Rooze⁷, Francisco J Pilar-Orive⁸, Walusa Assad Gonçalves-Ferri⁹, Angela Amigoni¹⁰, Werther Brunow de Carvalho¹¹, Vera Lucia Jornada Krebs¹², Niran Al-Naqeeb¹³, Olivier Danhaive¹⁴, Merih Cetinkaya¹⁵, Howard Stein¹⁶, Jessica Shoemaker¹⁶, Olivier Danhaive¹⁴, Paul Torpiano¹⁷, Susanne Vetter-Laracy¹⁸, Bjarte Rogdo¹⁹, Yasser Elsayed²⁰, Giovanna Chidini²¹, Martin Kneyber²², Alberto Medina Villanueva²³, Angelo Polito²⁴, Carole Nm Brouwer²⁵, Peter Rimensberger²⁴

Affiliations

¹ From the Division of Pediatrics and Neonatal Critical Care, "A.Beclere" Medical Center, Paris Saclay University Hospitals, APHP, Paris, France.
² Physiopathology and therapeutic innovation Unit-INSERM U999, Paris Saclay University, Paris, France.
³ Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia.
⁴ Department of Paediatrics, University of Melbourne, Melbourne, Australia.
⁵ Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
⁶ "Antoine Béclère" Medical Centre, Paris Saclay University Hospitals, APHP, France.
⁷ Hôpital Universitaire des enfants Reine Fabiola, Unités de soins intensifs, Laeken, Belgique.
⁸ Pediatrics Department - PICU, Biocruces Bizkaia Health Research Institute Cruces University Hospital, Barakaldo, Spain.
⁹ Department of Pediatrics, Ribeirão Preto Medical School - University of São Paulo, São Paulo State, Ribeirão Preto, Brazil.
¹⁰ Department of Pediatrics, Pediatric Intensive Care Unit, University Hospital of Padova, Padova, Italy.
¹¹ Pediatric Intensive Care/Neonatology of the Department of Pediatrics, Faculty of Medicine - University of São Paulo, São Paulo, Brazil.
¹² Division of Neonatology, Department of Pediatrics, Faculty of Medicine - University of São Paulo, São Paulo, Brazil.
¹³ Neonatal Department, AL-Adan Hospital, Ahmadi Area, Kuwait.
¹⁴ Division of Neonatology (Pediatrics), Catholic University of Louvain, Brussels, Belgium.
¹⁵ Department of Neonatology, Basaksehir, Cam and Sakura City Hospital, Istanbul, Turkey.
¹⁶ Division of Neonatology, Department of Pediatrics, Promedica Ebied Children's Hospital, Toledo, OH, USA.
¹⁷ Department of Paediatrics and Adolescent Health, Mater Dei Hospital, Msida, Malta.
¹⁸ University Hospital Son Espases/Balearic Island Health Research Institute - IdISBa, Palma, Spain.
¹⁹ NICU/PICU, Children's Hospital of Eastern Switzerland, St Gallen, Switzerland.
²⁰ Section of Neonatology, Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
²¹ Department of Anesthesia and Intensive Care, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Pediatric Intensive Care Unit, Milan, Italy.
²² Division of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Netherlands.
²³ Pediatric Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain.
²⁴ Pediatric and Neonatal Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
²⁵ Pediatric Intensive Care Unit, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 37463390
PMCID: PMC10348412
DOI: 10.1097/INF.0000000000003950

Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study

Daniele De Luca et al. Pediatr Infect Dis J. 2023.

. 2023 Aug 1;42(8):685-687.

doi: 10.1097/INF.0000000000003950. Epub 2023 Apr 18.

Authors

Collaborators

European Society of Pediatric and Neonatal Intensive Care COVID-19 Paediatric and Neonatal Registry Group and European society of pediatric and neonatal intensive care covid-19 paediatric and neonatal registry (EPICENTRE) group - group authorship:
Danilo Buonsenso⁵, Roberta Centorrino, Alexandre Vivanti⁶, Shancy Rooze⁷, Francisco J Pilar-Orive⁸, Walusa Assad Gonçalves-Ferri⁹, Angela Amigoni¹⁰, Werther Brunow de Carvalho¹¹, Vera Lucia Jornada Krebs¹², Niran Al-Naqeeb¹³, Olivier Danhaive¹⁴, Merih Cetinkaya¹⁵, Howard Stein¹⁶, Jessica Shoemaker¹⁶, Olivier Danhaive¹⁴, Paul Torpiano¹⁷, Susanne Vetter-Laracy¹⁸, Bjarte Rogdo¹⁹, Yasser Elsayed²⁰, Giovanna Chidini²¹, Martin Kneyber²², Alberto Medina Villanueva²³, Angelo Polito²⁴, Carole Nm Brouwer²⁵, Peter Rimensberger²⁴

Affiliations

¹ From the Division of Pediatrics and Neonatal Critical Care, "A.Beclere" Medical Center, Paris Saclay University Hospitals, APHP, Paris, France.
² Physiopathology and therapeutic innovation Unit-INSERM U999, Paris Saclay University, Paris, France.
³ Neonatal Research, Murdoch Children's Research Institute, Parkville, Australia.
⁴ Department of Paediatrics, University of Melbourne, Melbourne, Australia.
⁵ Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
⁶ "Antoine Béclère" Medical Centre, Paris Saclay University Hospitals, APHP, France.
⁷ Hôpital Universitaire des enfants Reine Fabiola, Unités de soins intensifs, Laeken, Belgique.
⁸ Pediatrics Department - PICU, Biocruces Bizkaia Health Research Institute Cruces University Hospital, Barakaldo, Spain.
⁹ Department of Pediatrics, Ribeirão Preto Medical School - University of São Paulo, São Paulo State, Ribeirão Preto, Brazil.
¹⁰ Department of Pediatrics, Pediatric Intensive Care Unit, University Hospital of Padova, Padova, Italy.
¹¹ Pediatric Intensive Care/Neonatology of the Department of Pediatrics, Faculty of Medicine - University of São Paulo, São Paulo, Brazil.
¹² Division of Neonatology, Department of Pediatrics, Faculty of Medicine - University of São Paulo, São Paulo, Brazil.
¹³ Neonatal Department, AL-Adan Hospital, Ahmadi Area, Kuwait.
¹⁴ Division of Neonatology (Pediatrics), Catholic University of Louvain, Brussels, Belgium.
¹⁵ Department of Neonatology, Basaksehir, Cam and Sakura City Hospital, Istanbul, Turkey.
¹⁶ Division of Neonatology, Department of Pediatrics, Promedica Ebied Children's Hospital, Toledo, OH, USA.
¹⁷ Department of Paediatrics and Adolescent Health, Mater Dei Hospital, Msida, Malta.
¹⁸ University Hospital Son Espases/Balearic Island Health Research Institute - IdISBa, Palma, Spain.
¹⁹ NICU/PICU, Children's Hospital of Eastern Switzerland, St Gallen, Switzerland.
²⁰ Section of Neonatology, Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
²¹ Department of Anesthesia and Intensive Care, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Pediatric Intensive Care Unit, Milan, Italy.
²² Division of Paediatric Critical Care Medicine, Department of Paediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Netherlands.
²³ Pediatric Intensive Care Unit, Hospital Universitario Central de Asturias, Oviedo, Spain.
²⁴ Pediatric and Neonatal Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
²⁵ Pediatric Intensive Care Unit, Leiden University Medical Center, Leiden, The Netherlands.

PMID: 37463390
PMCID: PMC10348412
DOI: 10.1097/INF.0000000000003950

Abstract

Neonatal Severe Acute Respiratory Syndrome-CoronaVirus-2 infections can be community-acquired or vertically-acquired. The analysis of neonatal patients requiring hospitalization reported in the EPICENTRE worldwide registry shows that community-acquired cases have clinical features (fever, respiratory signs, feeding difficulties, P < 0.0001) and received antibiotics (P = 0.014) more frequently than vertically-acquired patients. Severe Acute Respiratory Syndrome-CoronaVirus-2 infections should be considered in the clinical workout of neonatal infections.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

1. Raschetti R, Vivanti AJ, Vauloup-Fellous C, et al. . Synthesis and systematic review of reported neonatal SARS-CoV-2 infections. Nat Commun. 2020;11:5164. - PMC - PubMed
1. https://apps.who.int/iris/handle/10665/339422. Accessed April 13, 2023.
1. De Luca D, Rava L, Nadel S, et al. . The EPICENTRE (ESPNIC Covid pEdiatric Neonatal Registry) initiative: background and protocol for the international SARS-CoV-2 infections registry. Eur J Pediatr. 2020;179:1271–1278. - PMC - PubMed
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1. Schwartz DA, Baldewijns M, Benachi A, et al. . Chronic histiocytic intervillositis with trophoblast necrosis are risk factors associated with placental infection from coronavirus disease 2019 (COVID-19) and intrauterine maternal-fetal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in liveborn and stillborn infants. Arch Pathol Lab Med. 2021;145:517–528. - PubMed

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Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study

Collaborators

Affiliations

Community Versus Vertically Acquired Neonatal SARS-CoV-2 Infection: The EPICENTRE Cohort Study

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous