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. 2023 Jul 19;8(1):274.
doi: 10.1038/s41392-023-01532-2.

Cysteine carboxyethylation: a novel post-translational modification associated with autoimmune arthritis

Alessandro Didonna  1
Affiliations

Cysteine carboxyethylation: a novel post-translational modification associated with autoimmune arthritis

Alessandro Didonna. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Proposed model for ankylosing spondylitis (AS) pathogenesis. In specific metabolic conditions associated with increased levels of 3-hydroxypropionate (3-HPA), the enzyme cystathionine β-synthase (CBS) mediates the post-translational modification of cysteines via the addition of carboxyethyl groups. In the peripheral immune system, carboxyethylation of C96 residue in integrin αIIb (ITGA2B-ceC96) results in higher degradation of the modified protein with the consequent formation of immunogenic carboxyethylated peptides. Such peptides are presented by HLA-DR4 expressing professional antigen-presenting cells (APCs) to autoreactive CD4+ T cells which in turn start an aberrant immune response against AS target tissues. Cell-mediated autoimmunity is also accompanied by the secretion of autoantibodies against ITGA2B-ceC96, which further exacerbates AS pathology. All chemical structures were drawn using ChemSketch software
See this image and copyright information in PMC

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