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. 2023:1426:43-76.
doi: 10.1007/978-3-031-32259-4_3.

Life Course of Asthma

Sobia Farooq  1 , Sumita Khatri  2
Affiliations

Life Course of Asthma

Sobia Farooq et al. Adv Exp Med Biol. 2023.

Abstract

Asthma is a heterogeneous chronic airway disease that can vary over a lifetime. Although broad categories of asthma by severity and type have been constructed, there remains a tremendous opportunity to discover an approach to managing asthma with additional factors in mind. Many in the field have suggested and are pursuing a novel paradigm shift in how asthma might be better managed, considering the life course of exposures, management priorities, and predicted trajectory of lung function growth. This approach will require a more holistic view of prenatal, postnatal, adolescence, hormonal and gender aspects, and the aging process. In addition, the environment, externally and internally, including in one's genetic code and epigenetic changes, are factors that affect how asthma progresses or becomes more stable in individuals. This chapter focuses on the various influences that may, to differing degrees, affect people with asthma, which can develop at any time in their lives. Shifting the paradigm of thought and strategies for care and advocating for public policies and health delivery that focus on this philosophy is paramount to advance asthma care for all.

Keywords: Family history; Heterogeneity; Lung function; Prediction; Prenatal exposure; Trajectory; Vitamin D deficiency.

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References

    1. Szefler SJ. Asthma across the lifespan: time for a paradigm shift. J Allergy Clin Immunol. 2018;142(3):773–80. - PubMed
    1. Asthma, G.I.f. Global strategy for asthma management and prevention, 2022. 2022.
    1. Expert Panel Working Group of the National Heart, L., et al. 2020 Focused updates to the asthma management guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020;146(6):1217–70.
    1. Excellence, N.I.f.H.a.C. Asthma: diagnosis, monitoring and chronic asthma management. 2017. https://www.nice.org.uk/guidance/NG80/evidence .
    1. McGeachie MJ, et al. Patterns of growth and decline in lung function in persistent childhood asthma. N Engl J Med. 2016;374(19):1842–52. - PubMed - PMC