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. 2023 Jun;175(2):219-224.
doi: 10.1007/s10517-023-05838-7. Epub 2023 Jul 19.

Influence of Interleukin-2 and Brain-Derived Neurotrophic Factor (BDNF) on the Size of Myocardial Infarction in Rats with Systemic Inflammatory Response

I Yu Burovenko  1 , D L Sonin  1 , O V Borshcheva  1 , M S Istomina  1 , E A Zaitseva  1 , E S Protsak  1 , V Yu Borshchev  1 , Yu Yu Borshchev  1 , M M Galagudza  2
Affiliations

Influence of Interleukin-2 and Brain-Derived Neurotrophic Factor (BDNF) on the Size of Myocardial Infarction in Rats with Systemic Inflammatory Response

I Yu Burovenko et al. Bull Exp Biol Med. 2023 Jun.

Abstract

We studied the influence of recombinant IL-2 and brain-derived neurotrophic factor (BDNF) on the size of the myocardial necrosis zone of rats with systemic inflammatory response syndrome (SIRS). A significant increase in the necrosis zone and the levels of proinflammatory cytokines was revealed in animals with SIRS in comparison with the control. The administration of IL-2 to animals with SIRS significantly reduced the size of the necrosis zone, which was paralleled by a pronounced increase in IL-2 and BDNF in comparison with the corresponding parameters in rats with SIRS that did not receive IL-2. Administration of BDNF to animals with SIRS was followed by normalization of TNFα and IL-1α levels, but did not lead to a decrease in the size of the necrosis zone.

Keywords: brain-derived neurotrophic factor; interleukin-2; myocardial infarction; size of the necrosis zone; systemic inflammatory response syndrome.

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