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. 2023 Dec;30(6):2644-2654.
doi: 10.1007/s12350-023-03336-x. Epub 2023 Jul 18.

Accurate and efficient rapid acquisition early post-injection stress-first CZT SPECT myocardial perfusion imaging with tetrofosmin and attenuation correction

James A Case  1 , Staci A Courter  2 , AIain McGhie  3 , Krishna K Patel  3   4 , Brett W Sperry  3 , Erin Moloney  3 , Katrina O Case  2   5 , Eric V Burgett  3 , Timothy M Bateman  2   3
Affiliations

Accurate and efficient rapid acquisition early post-injection stress-first CZT SPECT myocardial perfusion imaging with tetrofosmin and attenuation correction

James A Case et al. J Nucl Cardiol. 2023 Dec.

Abstract

Introduction: Myocardial perfusion imaging (MPI) protocols have not changed significantly despite advances in instrumentation and software. We compared an early post-injection, stress-first SPECT protocol to standard delayed imaging.

Methods: 95 patients referred for SPECT MPI were imaged upright and supine on a Spectrum Dynamics D-SPECT CZT system with CT attenuation correction. Patients received injection of 99mTc tetrofosmin at peak of regadenoson stress and were imaged. Early post-stress (mean 17 ± 2 minutes) and Standard 1-h delay (mean 61 ± 13 min). Three blinded readers evaluated images for overall interpretation, perceived need for rest imaging, image quality, and reader confidence. Laboratory efficiency was also evaluated.

Results: Blinded readers had the same response for the need for rest in 77.9% of studies. Studies also had the same interpretation in 89.5% of studies. Reader confidence was high (86.0% (Early) and 90.3% (Standard p = 0.52. Image quality was good or excellent in 87.4% Early vs 96.8% Standard (p = 0.09). Time between patient check-in and end of stress imaging was 104 ± (Standard) to 60 ± 18 minutes (Early) (p < 0.001).

Conclusion: Early post-injection stress-only imaging using CZT SPECT/CT appears promising with Tc-99m tetrofosmin with similar image quality, reader confidence, diagnosis, and need for a rest scan.

Keywords: CZT instrumentation; Early SPECT imaging; Tetrofosmin.

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References

    1. Skali H, Murthy VL, Al-Mallah MH, et al. Guidance and best practices for nuclear cardiology laboratories during the coronavirus disease 2019 (COVID-19) pandemic: an information statement from ASNC and SNMMI. J Nucl Cardiol 2020;27:1022‐9. - DOI - PubMed - PMC
    1. Thompson RC, Phillips LM, Dilsizian V, et al. Update on guidance and best practices for nuclear cardiology laboratories during the coronavirus disease 2019 (COVID-19) pandemic: emphasis on transition to chronic endemic state. An information statement from ASNC, IAEA, and SNMMI. J Nucl Cardiol 2022;29:1‐6. - DOI
    1. Skali H, Murthy VL, Paez D, et al. Guidance and best practices for reestablishment of non-emergent care in nuclear cardiology laboratories during the coronavirus disease 2019 (COVID-19) pandemic: an information statement from ASNC, IAEA, and SNMMI: endorsed by the Infectious Diseases Society of America. J Nucl Cardiol 2020;27:1855‐62. - DOI - PubMed - PMC
    1. Skulstad H, Cosyns B, Popescu BA, et al. COVID-19 pandemic and cardiac imaging: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel. Eur Heart J 2020;21:592‐8.
    1. Katsikis A, Theodorakos A, Kouzoumi A, Kitziri E, Georgiou E, Koutelou M. Fast myocardial perfusion imaging with (99m)Tc in challenging patients using conventional SPECT cameras. J Nucl Cardiol 2017;24:1314‐27. - DOI - PubMed

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