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Case Reports
. 2023 Jul 18;24(1):214.
doi: 10.1186/s12882-023-03079-4.

Hypokalemia after rituximab administration in nephrotic syndrome: two case reports

Yiyun Song #  1 , Lin Ding #  1 , Xin An  1 , Yi Zhao  1 , Xianhua Li  1 , Xiangdong Yang  2 , Xiaoyan Xiao  3
Affiliations
Case Reports

Hypokalemia after rituximab administration in nephrotic syndrome: two case reports

Yiyun Song et al. BMC Nephrol. .

Abstract

Rituximab, a chimeric anti-CD20 monoclonal antibody, is an effective treatment for nephrotic syndrome. Hypokalemia is a rare adverse reaction among patients treated with rituximab although there have been extensive reports of acute and chronic adverse events with the administration of rituximab. We herein report two cases of symptomatic hypokalemia after intravenous rituximab administration in our center, to help health professionals consider the possibility of acute hypokalemia after rituximab administration, monitor potassium timely and develop an appropriate treatment plan.

Keywords: Hypokalemia; Nephrotic syndrome; Rituximab.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Fig. 1
Fig. 1
Potassium levels of case 1 (mmol/L) over time and laboratory normal value (3.5 mmol/L, dotted line). K, potassium (mmol/L); RTX, rituximab; h, hour
Fig. 2
Fig. 2
Potassium levels of case 2 (mmol/L) over time and laboratory normal value (3.5 mmol/L, dotted line). K, potassium (mmol/L); RTX, rituximab; h, hour; d, day
See this image and copyright information in PMC

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