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Meta-Analysis
. 2023 Jul 18;23(1):153.
doi: 10.1186/s12902-023-01408-0.

Prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa: a systematic review and meta-analysis

Ermiyas Alemayehu  1 , Temesgen Fiseha  2 , Getachew Mesfin Bambo  3 , Samuel Sahile Kebede  3 , Habtye Bisetegn  2 , Mihret Tilahun  2 , Habtu Debash  2 , Hussen Ebrahim  2 , Ousman Mohammed  2 , Melaku Ashagrie Belete  2 , Alemu Gedefie  2
Affiliations
Meta-Analysis

Prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa: a systematic review and meta-analysis

Ermiyas Alemayehu et al. BMC Endocr Disord. .

Abstract

Background: Hyperuricemia increases morbidity and mortality in type 2 diabetic individuals. It is linked to the expansion of diabetes and cardiovascular diseases indicators, as well as being a significant predictor of coronary artery disease. It also leads to a poor prognosis and increment of diabetic complications including diabetic neuropathy, retinopathy, and nephropathy. Therefore, this systematic review and meta-analysis was aimed to determine the pooled prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa.

Methods: We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. To identify relevant articles, we searched electronic databases such as PubMed, Google Scholar, African Journal Online, Science Direct, Embase, ResearchGate, Scopus, and Web of Sciences. The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. Statistical analysis was performed using Stata 14.0 software. To evaluate heterogeneity, we utilized Cochran's Q test and I2 statistics. Publication bias was assessed through the examination of a funnel plot and Egger's test. The pooled prevalence was estimated using a random effect model. Furthermore, sub-group and sensitivity analyses were conducted.

Results: The overall pooled prevalence of hyperuricemia among type 2 diabetic patients in Africa was 27.28% (95% CI: 23.07, 31.49). The prevalence was highest in Central Africa 33.72% (95% CI: 23.49, 43.95), and lowest in North Africa 24.72% (95% CI: 14.38, 35.07). Regarding sex, the pooled prevalence of hyperuricemia among female and male type 2 diabetic patients was 28.02% (95% CI: 22.92, 33.48) and 28.20% (95% CI: 22.92, 33.48), respectively.

Conclusion: This systematic review and meta-analysis showed a high prevalence of hyperuricemia among type 2 diabetic patients. So, regular screening and diagnosis of hyperuricemia required for preventing its pathological effects and contribution to chronic complications of diabetes.

Systematic review registration: PROSPERO (2022: CRD42022331279).

Keywords: Africa; Hyperuricemia; Meta-analysis; Prevalence; Systematic review; Type 2 diabetes.

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Conflict of interest statement

The authors declared that no competing interest for their work.

Figures

Fig. 1
Fig. 1
Flow diagram of the included studies for the systematic review and meta-analysis of the prevalence of hyperuricemia in Africa
Fig. 2
Fig. 2
Forest plot showing the pooled prevalence of hyperuricemia among T2DM patients in Africa from random-effect model analysis
Fig. 3
Fig. 3
Forest plot showing the pooled prevalence of hyperuricemia by sub-region
Fig. 4
Fig. 4
Forest plot showing the pooled prevalence of hyperuricemia by sex of the study participants
Fig. 5
Fig. 5
Forest plot showing the pooled prevalence of hyperuricemia by country
Fig. 6
Fig. 6
Forest plot showing the pooled prevalence of hyperuricemia by year of publication
Fig. 7
Fig. 7
Funnel plot on the prevalence of hyperuricemia among T2DM patients in Africa
See this image and copyright information in PMC

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References

    1. Rossi G, Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2018;33(Suppl 1):62–S9. - PMC - PubMed
    1. Leslie RD, Palmer J, Schloot NC, Lernmark A. Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment. Diabetologia. 2016;59(1):13–20. doi: 10.1007/s00125-015-3789-z. - DOI - PubMed
    1. Ramtahal R, Khan C, Maharaj-Khan K, Nallamothu S, Hinds A, Dhanoo A, et al. Prevalence of self-reported sleep duration and sleep habits in type 2 diabetes patients in South Trinidad. J Epidemiol global health. 2015;5(4):35–S43. doi: 10.1016/j.jegh.2015.05.003. - DOI - PMC - PubMed
    1. Patterson CC, Harjutsalo V, Rosenbauer J, Neu A, Cinek O, Skrivarhaug T, et al. Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 european centres in the 25 year period 1989–2013: a multicentre prospective registration study. Diabetologia. 2019;62(3):408–17. doi: 10.1007/s00125-018-4763-3. - DOI - PubMed
    1. Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183:109119. doi: 10.1016/j.diabres.2021.109119. - DOI - PMC - PubMed