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. 2023 Dec;49(3):530-536.
doi: 10.1111/aej.12776. Epub 2023 Jul 18.

Efficacy of mixed diclofenac solutions against root canal biofilms

Carmen Maria Ferrer-Luque  1   2 , Carmen Solana  2 , Beatriz Aguado  3 , Pilar Baca  1   2 , María Teresa Arias-Moliz  2   4 , Matilde Ruiz-Linares  1   2
Affiliations

Efficacy of mixed diclofenac solutions against root canal biofilms

Carmen Maria Ferrer-Luque et al. Aust Endod J. 2023 Dec.

Abstract

The objective of this research was to evaluate the efficacy of diclofenac sodium solutions, with or without cetrimide (CTR) added, against polymicrobial root canal biofilms grown in dentin specimens. The study groups were: (1) 5% diclofenac sodium (DCS); (2) 2.5% DCS; (3) 2.5% DCS + 0. 2% CTR; (4) 2.5% DCS + 0.4% CTR and (5) 0.9% saline solution (SS) as the control. After 5 min of solution contact with the biofilms, the antimicrobial activity was evaluated by means of the adenosine triphosphate (ATP) assay as well as confocal laser scanning microscopy (CLSM). Microbial quantification was indicated as the percentage reduction of relative light units (RLUs) for the ATP assay, the Log10 total biovolume and the viability percentage (green cells) for CLSM. Solutions of 2.5% DCS + 0.4% CTR and 5% DCS showed the highest antimicrobial efficacy. Cetrimide increased the antibiofilm activity of diclofenac sodium against endodontic biofilms.

Keywords: antimicrobial activity; cetrimide; diclofenac; polymicrobial biofilm; root canal dentin.

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References

REFERENCES

    1. Smith SR, Deshpande BR, Collins JE, Katz JN, Losina E. Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review. Osteoarthr Cartil. 2016;24(6):962-72.
    1. Derry S, Conaghan P, Da Silva JA, Wiffen PJ, Moore RA. Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database Syst Rev. 2016;4:CD007400.
    1. Derwich M, Mitus-Kenig M, Pawlowska E. Orally administered NSAIDs-general characteristics and usage in the treatment of temporomandibular joint osteoarthritis-a narrative review. Pharmaceuticals (Basel). 2021;14(3):219.
    1. Altman R, Bosch B, Brune K, Patrignani P, Young C. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015;75(8):859-77.
    1. Tieppo Francio V, Davani S, Towery C, Brown TL. Oral versus topical diclofenac sodium in the treatment of osteoarthritis. J Pain Palliat Care Pharmacother. 2017;31(2):113-20.

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