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. 2023 Jul;95(7):e28964.
doi: 10.1002/jmv.28964.

Detection of parechovirus-A in hospitalized children with acute lower respiratory infection in Myanmar, 2017-2018

Jun Tachikawa  1 , Yuta Aizawa  1 , Tetsuya Kobayashi  1 , Tatsuki Ikuse  1 , Kazuhiro Kamata  1   2 , Su Mon Kyaw Win  2 , Lasham Di Ja  2 , Khin Nyo Thein  3 , Nay Chi Win  2 , Aye Thida  4 , Aye Tun  5 , Yuko Suzuki  1 , Ai Ito  1 , Hidekazu Osada  2   6 , Irina Chon  6 , Wint Wint Phyu  6 , Tomomi Ota  2 , Yadanar Kyaw  4 , Htay Htay Tin  7 , Kanako Watanabe  8 , Yugo Shobugawa  9 , Hisami Watanabe  2 , Reiko Saito  6 , Akihiko Saitoh  1
Affiliations

Detection of parechovirus-A in hospitalized children with acute lower respiratory infection in Myanmar, 2017-2018

Jun Tachikawa et al. J Med Virol. 2023 Jul.

Abstract

Parechovirus-A (PeV-A) causes emerging infection in children, and clinical presentation depends on genotype. The virus has been investigated mainly in developed countries; however, data from developing countries, especially in Asia, are sparse. This study investigated whether PeV-A circulated in children in Myanmar. This retrospective study evaluated PeV-A in nasopharyngeal samples from children aged 1 month to 12 years who were hospitalized with acute lower respiratory infection at Yankin Children Hospital, Yangon, Myanmar, during the period from May 2017 to April 2019. Real-time polymerase chain reaction (PCR) was used to detect PeV-A, and PCR-positive samples were used for genotyping and phylogenetic analysis. In total, 11/570 (1.9%) of samples were positive for PeV-A; 7 were successfully genotyped by sequencing the VP3/VP1 region, as follows: PeV-A1 (n = 4), PeV-A5 (n = 1), PeV-A6 (n = 1), and PeV-A14 (n = 1). Median age was 10.0 months (interquartile range 4.0-12.0 months), and other respiratory viruses were detected in all cases. Phylogenetic analysis showed that all detected PeV-A1 strains were in clade 1 A, which was a minor clade worldwide. Four PeV-A genotypes were detected in Myanmar. The clinical impact of PeV-A in children should be evaluated in future studies.

Keywords: Myanmar; acute lower respiratory infection; children; emerging infection; parechovirus.

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References

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