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. 2024 Jan;20(1):112-123.
doi: 10.1002/alz.13381. Epub 2023 Jul 19.

The MINT Sprint 2.0: A picture naming test for detection of naming impairments in Alzheimer's disease and in preclinical AD

Tamar H Gollan  1 , Dalia L Garcia  2 , Alena Stasenko  1 , Mayra Murillo  1 , Chi Kim  3 , Douglas Galasko  3 , David P Salmon  3
Affiliations

The MINT Sprint 2.0: A picture naming test for detection of naming impairments in Alzheimer's disease and in preclinical AD

Tamar H Gollan et al. Alzheimers Dement. 2024 Jan.

Abstract

Introduction: Evidence on the onset of naming deficits in Alzheimer's disease (AD) is mixed. Some studies showed an early decline, but others did not. The present study introduces evidence from a novel naming test.

Methods: Cognitively normal (n = 138), mild cognitive impairment (MCI; n = 21), and Alzheimer's disease (AD; n = 31) groups completed an expanded Multilingual Naming Test with a time-pressured administration procedure (MINT Sprint 2.0). Cerebrospinal fluid biomarkers classified participants as true controls (n = 61) or preclinical AD (n = 26).

Results: Total correct MINT Sprint 2.0 scores exhibited good sensitivity and specificity (>0.85) for discriminating true controls from cognitively impaired (MCI/AD) groups and showed significant differences between true controls and preclinical AD groups. Time measurement did not improve classification, but percent resolved scores exhibited promise as an independent AD marker.

Discussion: Naming deficits can be detected in the earliest stages of AD with tests and procedures designed for this purpose.

Keywords: aging; cerebrospinal fluid biomarkers; multilingual naming test (MINT); picture naming; preclinical Alzheimer's disease; speeded naming.

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Conflict of interest statement

Authors T.H.G., D.G., A.S., C.K., and M.M. have no conflicts of interest to declare. D.P.S. is a consultant for Aptinyx and Biogen. D.G. is a consultant for Biogen, Fujirebio, Cognition Therapeutics, Amprion, vTv Pharmaceuticals, and GE Healthcare. Author disclosures are available in the supporting information.

Figures

FIGURE 1
FIGURE 1
Receiver operating characteristic curves classifying participants as being either mild cognitive impairment/Alzheimer's disease or true controls without elevated risk (i.e., biomarker negative; see Tables 1 and 4). MINT, Multilingual Naming Test
FIGURE 2
FIGURE 2
Correlation between age at testing and the PR score in true controls (i.e., biomarker negative, n = 61), preclinical AD (i.e., biomarker positive; n = 26), and cognitively impaired participants (i.e., MCI or AD, n = 52; see Table 1). AD, Alzheimer's disease; MCI, mild cognitive impairment; MINT, Multilingual Naming Test; PR, percent resolved
FIGURE 3
FIGURE 3
MINT Sprint 2.0 total correct scores were highest in true controls (i.e., biomarker negative, n = 61), significantly lower in preclinical AD (i.e., biomarker positive; n = 26), and lower still in cognitively impaired participants (i.e., MCI or AD, n = 52; see Table 1). AD, Alzheimer's disease; CI, confidence interval; MCI, mild cognitive impairment; MINT, Multilingual Naming Test; PR, percent resolved
See this image and copyright information in PMC

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