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Review
. 2023 Aug;23(8):304-311.
doi: 10.1016/j.bjae.2023.04.001. Epub 2023 Jun 7.

The persistent effects of anaesthesia on the brain

R Horan  1 , C Sortica da Costa  1 , P Nambyiah  1
Affiliations
Review

The persistent effects of anaesthesia on the brain

R Horan et al. BJA Educ. 2023 Aug.
No abstract available

Keywords: neurocognitive disorders; neuronal plasticity; neuroprotection.

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Conflict of interest statement

The authors declare they have no conflicts of interest.

Figures

Figure 1
Fig 1
Light microscope images from rat brain slices, either control (A, F, H, J) or exposed to a cocktail of midazolam, nitrous oxide and isoflurane (B–E, G, I, K, L). Images are of the posterior cingulate/retrosplenial cortex (A-C), subiculum (D, E), anterior thalamus (F, G), rostral CA1 hippocampus (H, I) and parietal cortex (J-L). The nuclei shown in the anterior thalamus (F, G) are laterodorsal (LD), anterodorsal (AD), anteroventral (AV), anteromedial (AM), and nucleus reuniens (NR). Staining reveals extensive evidence of neuroapoptosis in the rats exposed to the anaesthetic cocktail. (M) And (N) are electron micrograph images of neurones undergoing apoptosis (M early, N late). Reproduced from Jevtovic-Tororovic and colleagues, 2003, with permission from The Journal of Neuroscience. Copyright 2003 Society for Neuroscience.
See this image and copyright information in PMC

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