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. 2023 Jul 18;16(7):1100-1109.
doi: 10.18240/ijo.2023.07.15. eCollection 2023.

Structural measurements and vessel density of spectral-domain optic coherence tomography in early, moderate, and severe primary angle-closure glaucoma

Wei Jiang  1 , Nan Jiang  1 , Gui-Bo Liu  1 , Jing Lin  1 , Cui Li  1 , Gui-Qiu Zhao  1
Affiliations

Structural measurements and vessel density of spectral-domain optic coherence tomography in early, moderate, and severe primary angle-closure glaucoma

Wei Jiang et al. Int J Ophthalmol. .

Abstract

Aim: To compare the macular ganglion cell-inner plexiform layer (GCIPL) thickness, retinal nerve fiber layer (RNFL) thickness, optic nerve head (ONH) parameters, and retinal vessel density (VD) measured by spectral-domain optical coherence tomography (SD-OCT) and analyze the correlations between them in the early, moderate, severe primary angle-closure glaucoma (PACG) and normal eyes.

Methods: Totally 70 PACG eyes and 20 normal eyes were recruited for this retrospective analysis. PACG eyes were further separated into early, moderate, or severe PACG eyes using the Enhanced Glaucoma Staging System (GSS2). The GCIPL thickness, RNFL thickness, ONH parameters, and retinal VD were measured by SD-OCT, differences among the groups and correlations within the same group were calculated.

Results: The inferior and superotemporal sectors of the GCIPL thickness, rim area of ONH, average and inferior sector of the retinal VD were significantly reduced (all P<0.05) in the early PACG eyes compared to the normal and the optic disc area, cup to disc ratio (C/D), and cup volume were significantly higher (all P<0.05); but the RNFL was not significant changes in early and moderate PACG. In severe group, the GCIPL and RNFL thickness were obvious thinning with retinal VD were decreasing as well as C/D and cup volume increasing than other three groups (all P<0.01). In the early PACG subgroup, there were significant positive correlations between retinal VD and GCIPL thickness (except superonasal and inferonasal sectors, r=0.573 to 0.641, all P<0.05), superior sectors of RNFL thickness (r=0.055, P=0.049). More obvious significant positive correlations were existed in moderate PACG eyes between retinal VD and superior sectors of RNFL thickness (r=0.650, P=0.022), and temporal sectors of RNFL thickness (r=0.740, P=0.006). In the severe PACG eyes, neither GCIPL nor RNFL thickness was associated with retinal VD.

Conclusion: The ONH damage and retinal VD loss appears earlier than RNFL thickness loss in PACG eyes. As the PACG disease progressed from the early to the moderate stage, the correlations between the retinal VD and RNFL thickness increases.

Keywords: ganglion cell-inner plexiform layer; optic coherence tomography; optic nerve head; primary angle-closure glaucoma; retinal nerve fiber layer; retinal vessel density.

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Figures

Figure 1
Figure 1. Structural parameters
A: Macular ganglion cell-inner plexiform layer (GCIPL) parameters obtained by spectral-domain optic coherence tomography (SD-OCT); B: Retinal nerve fiber layer (RNFL) and optic nerve head (ONH) parameters obtained by SD-OCT.
Figure 2
Figure 2. Vessel density and choroidal thickness parameters
A, B: Retinal vessel density (VD) obtained by optic coherence tomography angiography (OCTA); C: Retinal VD detected by AngioTool software; D: Choroidal thickness obtained by SD-OCT (HD 1 Line 100×).
See this image and copyright information in PMC

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