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Meta-Analysis
. 2023 Aug;27(8):4157-4171.
doi: 10.1007/s00784-023-05151-7. Epub 2023 Jul 19.

Prevalence of postoperative pain after endodontic treatment using low and high concentrations of sodium hypochlorite: a systematic review and meta-analysis

Rayssa Sabino-Silva  1 , Ihan Vitor Cardoso  1 , Filipe Colombo Vitali  1 , Ana Maria Hecke Alves  1 , Beatriz Dulcineia Mendes Souza  1 , Eduardo Antunes Bortoluzzi  2 , Lucas da Fonseca Roberti Garcia  1 , Cleonice da Silveira Teixeira  3
Affiliations
Meta-Analysis

Prevalence of postoperative pain after endodontic treatment using low and high concentrations of sodium hypochlorite: a systematic review and meta-analysis

Rayssa Sabino-Silva et al. Clin Oral Investig. 2023 Aug.

Abstract

Objectives: To determine the prevalence of postoperative pain after endodontic treatment using low (LC) and high (HC) concentrations of sodium hypochlorite (NaOCl).

Materials and methods: Six databases and the grey literature were searched to identify randomized clinical trials that evaluated postoperative pain after endodontic treatment using NaOCl. NaOCl concentrations were dichotomized into 'LC' (0.5% to 3%) and 'HC' (≥ 5%) and a proportion meta-analysis was applied to determine the postoperative pain prevalence: overall and according to pain intensity and postoperative time. The prevalence of patients using pain control medication was also determined. A significance level of 5% and a random effect model were applied for data analysis. Between-study heterogeneity was assessed by I2 index. Risk of bias (RoB) was assessed using the Cochrane Risk-of-Bias 2.0 tool. The certainty of evidence was assessed using the GRADE approach.

Results: Ten studies were included in the review and eight in the meta-analysis. The overall prevalence of postoperative pain was 45% in LC and 39% in HC. The prevalence of pain in LC and HC after 24 h was 25% and 40%, respectively. After 48 h, the prevalence decreased to 10% in LC and 25% in HC. 'Absent pain' was the most prevalent score. The prevalence of patients who used medication was 9% in LC and 15% in HC. Three studies were classified as 'high RoB', five as 'low RoB', and two as 'some concerns'. The certainty of evidence was very low.

Conclusions: The overall prevalence of postoperative pain after endodontic treatment using LC and HC of NaOCl was 45% and 39%, respectively.

Clinical relevance: Postoperative pain is common after endodontic treatment using NaOCl, but tends to decrease over time.

Keywords: Endodontics; Irrigating solution; Postoperative pain; Sodium hypochlorite; Systematic review.

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