. 2023 Aug:113:105517.

doi: 10.1016/j.parkreldis.2023.105517. Epub 2023 Jul 14.

MAPT allele and haplotype frequencies in Nigerian Africans: Population distribution and association with Parkinson's disease risk and age at onset

Olaitan Okunoye¹, Oluwadamilola O Ojo², Oladunni Abiodun³, Sani Abubakar⁴, Charles Achoru⁵, Olaleye Adeniji⁶, Osigwe Agabi², Uchechi Agulanna⁷, Rufus Akinyemi⁸, Mohammed Ali⁹, Ifeyinwa Ani-Osheku¹⁰, Ohwotemu Arigbodi¹¹, Abiodun Bello¹², Cyril Erameh¹³, Temitope Farombi¹⁴, Michael Fawale¹⁵, Frank Imarhiagbe¹⁶, Emmanuel Iwuozo¹⁷, Morenikeji Komolafe¹⁵, Paul Nwani¹⁸, Ernest Nwazor¹⁹, Yakub Nyandaiti²⁰, Yahaya Obiabo²¹, Olanike Odeniyi²², Francis Odiase¹⁶, Francis Ojini², Gerald Onwuegbuzie²³, Godwin Osaigbovo⁵, Nosakhare Osemwegie²⁴, Olajumoke Oshinaike²⁵, Folajimi Otubogun²⁶, Shyngle Oyakhire²⁷, Simon Ozomma²⁸, Sarah Samuel²⁰, Funmilola Taiwo¹³, Kolawole Wahab²⁹, Yusuf Zubair²⁷, Dena Hernandez³⁰, Sara Bandres-Ciga³¹, Cornelis Blauwendraat³², Andrew Singleton³², Henry Houlden¹, John Hardy¹, Mie Rizig¹, Njideka Okubadejo³³

Affiliations

¹ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, WC1N 3BG, United Kingdom.
² College of Medicine, University of Lagos, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria; Lagos University Teaching Hospital, Idi-araba, Lagos State, Nigeria.
³ General Hospital, Isolo, Lagos State, Nigeria.
⁴ Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
⁵ Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
⁶ Federal Medical Centre, Abeokuta, Ogun State, Nigeria.
⁷ Lagos University Teaching Hospital, Idi-araba, Lagos State, Nigeria.
⁸ Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
⁹ Federal Teaching Hospital Gombe, Gombe State, Nigeria.
¹⁰ Asokoro District Hospital, Asokoro, Abuja, Nigeria.
¹¹ Delta State University, Abraka, Delta State, Nigeria.
¹² University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
¹³ Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
¹⁴ University College Hospital, Ibadan, Oyo State, Nigeria.
¹⁵ Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
¹⁶ University of Benin, Benin City, Edo State, Nigeria.
¹⁷ Benue State University, Makurdi, Benue State, Nigeria.
¹⁸ Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.
¹⁹ Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
²⁰ University of Maiduguri Teaching Hospital, Maiduguri, Borno State, Nigeria.
²¹ Federal University of Health Sciences, Otukpo, Benue State, Nigeria.
²² General Hospital, Lagos Island, Lagos State, Nigeria.
²³ University of Abuja, Abuja, Federal Capital Territory, Nigeria.
²⁴ University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.
²⁵ Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
²⁶ Federal Medical Center, Ebute Metta, Lagos State, Nigeria.
²⁷ National Hospital, Abuja, Federal Capital Territory, Nigeria.
²⁸ University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
²⁹ University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria; University of Ilorin, Ilorin, Kwara State, Nigeria.
³⁰ Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20814, USA.
³¹ Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20814, USA.
³² Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20814, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20814, USA.
³³ College of Medicine, University of Lagos, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria; Lagos University Teaching Hospital, Idi-araba, Lagos State, Nigeria. Electronic address: nokubadejo@unilag.edu.ng.

PMID: 37467655
DOI: 10.1016/j.parkreldis.2023.105517

MAPT allele and haplotype frequencies in Nigerian Africans: Population distribution and association with Parkinson's disease risk and age at onset

Olaitan Okunoye et al. Parkinsonism Relat Disord. 2023 Aug.

. 2023 Aug:113:105517.

doi: 10.1016/j.parkreldis.2023.105517. Epub 2023 Jul 14.

Authors

Affiliations

¹ Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, WC1N 3BG, United Kingdom.
² College of Medicine, University of Lagos, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria; Lagos University Teaching Hospital, Idi-araba, Lagos State, Nigeria.
³ General Hospital, Isolo, Lagos State, Nigeria.
⁴ Ahmadu Bello University, Zaria, Kaduna State, Nigeria.
⁵ Jos University Teaching Hospital, Jos, Plateau State, Nigeria.
⁶ Federal Medical Centre, Abeokuta, Ogun State, Nigeria.
⁷ Lagos University Teaching Hospital, Idi-araba, Lagos State, Nigeria.
⁸ Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.
⁹ Federal Teaching Hospital Gombe, Gombe State, Nigeria.
¹⁰ Asokoro District Hospital, Asokoro, Abuja, Nigeria.
¹¹ Delta State University, Abraka, Delta State, Nigeria.
¹² University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
¹³ Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria.
¹⁴ University College Hospital, Ibadan, Oyo State, Nigeria.
¹⁵ Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
¹⁶ University of Benin, Benin City, Edo State, Nigeria.
¹⁷ Benue State University, Makurdi, Benue State, Nigeria.
¹⁸ Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.
¹⁹ Rivers State University Teaching Hospital, Port Harcourt, Rivers State, Nigeria.
²⁰ University of Maiduguri Teaching Hospital, Maiduguri, Borno State, Nigeria.
²¹ Federal University of Health Sciences, Otukpo, Benue State, Nigeria.
²² General Hospital, Lagos Island, Lagos State, Nigeria.
²³ University of Abuja, Abuja, Federal Capital Territory, Nigeria.
²⁴ University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.
²⁵ Lagos State University College of Medicine, Ikeja, Lagos State, Nigeria.
²⁶ Federal Medical Center, Ebute Metta, Lagos State, Nigeria.
²⁷ National Hospital, Abuja, Federal Capital Territory, Nigeria.
²⁸ University of Calabar Teaching Hospital, Calabar, Cross River State, Nigeria.
²⁹ University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria; University of Ilorin, Ilorin, Kwara State, Nigeria.
³⁰ Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20814, USA.
³¹ Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20814, USA.
³² Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20814, USA; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20814, USA.
³³ College of Medicine, University of Lagos, Lagos University Teaching Hospital, Idi Araba, Lagos State, Nigeria; Lagos University Teaching Hospital, Idi-araba, Lagos State, Nigeria. Electronic address: nokubadejo@unilag.edu.ng.

PMID: 37467655
DOI: 10.1016/j.parkreldis.2023.105517

Abstract

Introduction: The association between MAPT and PD risk may be subject to ethnic variability even within populations of similar geographical origin. Data on MAPT haplotype frequencies, and its association with PD risk in black Africans are lacking. We aimed to determine the frequencies of MAPT haplotypes and their role as risk factors for PD and age at onset in Nigerians.

Methods: The haplotype and genotype frequencies of MAPT rs1052553 were analysed in 907 individuals with PD and 1022 age-matched healthy controls from the Nigeria Parkinson's Disease Research network cohort. Clinical data related to PD included age at study, age at onset (AAO), and disease duration.

Results: The frequency of the H1 haplotype was 98.7% in PD, and 99.1% in controls (p = 0.19). The H2 haplotype was present in - 1.3% of PD and 0.9% of controls (p = 0.24). The most frequent MAPT genotype was H1H1 (PD - 97.5%, controls - 98.2%). The H1 haplotype was not associated with PD risk after accounting for gender and AAO (Odds ratio for H1/H1 vs H1/H2 and H2/H2: 0.68 (95% CI:0.39-1.28); p = 0.23).

Conclusions: Our findings support previous studies that report a low frequency of the MAPT H2 haplotype in black ancestry Africans but document its occurrence in Nigerians. The MAPT H1 haplotype was not associated with an increased risk or age at onset of PD in this cohort.

Keywords: Africa; Black ancestry; Genetics; H1 haplotype; H2 haplotype; MAPT; Nigeria; Parkinson's disease.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest R.A. is supported by the following grants: US NIH/NHGRI (U01HG010273) and the UK Royal Society/African Academy of Sciences (FLR/R1/191813). M.R. received funding from the University College London Grand challenges Small Grants (Award ID:177813 and the Michael J Fox Foundation Genetic Diversity in Parkinson's Disease 2019 (Grant ID:17483). H.H. is supported by the Michael J Fox Foundation Genetic Diversity in Parkinson's Disease (Grant ID: 17483). N.U.O. is supported by the Michael J Fox Foundation Genetic Diversity in Parkinson's Disease 2019 (Grant ID:17483) and the TETFund National Research Fund (NRF) 2019. S.B.-C., C.B. and A.S. are supported by the Intramural Research Program, National Institute on Aging, National Institutes of Health and US Department of Health and Human Services project ZO1 AG000949 and all these authors declare no non-financial competing interests. The remaining authors declare no competing interests.

Update of

MAPT allele and haplotype frequencies in Nigerian Africans: population distribution and association with Parkinson's disease risk and age at onset.
Okunoye O, Ojo O, Abiodun O, Abubakar S, Achoru C, Adeniji O, Agabi O, Agulanna U, Akinyemi R, Ali M, Ani-Osheku I, Arigbodi O, Bello A, Erameh C, Farombi T, Fawale M, Imarhiagbe F, Iwuozo E, Komolafe M, Nwani P, Nwazor E, Nyandaiti Y, Obiabo Y, Odeniyi O, Odiase F, Ojini F, Onwuegbuzie G, Osaigbovo G, Osemwegie N, Oshinaike O, Otubogun F, Oyakhire S, Ozomma S, Samuel S, Taiwo F, Wahab K, Zubair Y, Hernandez D, Bandres-Ciga S, Blauwendraat C, Singleton A, Houlden H, Hardy J, Rizig M, Okubadejo N. Okunoye O, et al. medRxiv [Preprint]. 2023 Mar 24:2023.03.24.23287684. doi: 10.1101/2023.03.24.23287684. medRxiv. 2023. Update in: Parkinsonism Relat Disord. 2023 Aug;113:105517. doi: 10.1016/j.parkreldis.2023.105517. PMID: 36993627 Free PMC article. Updated. Preprint.

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Supplementary concepts

Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

MAPT allele and haplotype frequencies in Nigerian Africans: Population distribution and association with Parkinson's disease risk and age at onset

Affiliations

MAPT allele and haplotype frequencies in Nigerian Africans: Population distribution and association with Parkinson's disease risk and age at onset

Authors

Affiliations

Abstract

Conflict of interest statement

Update of

Publication types

MeSH terms

Substances

Supplementary concepts

Grants and funding

LinkOut - more resources

Full Text Sources

Medical