Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jul 18;4(7):101117.
doi: 10.1016/j.xcrm.2023.101117.

Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines

Camille Chauvin  1 , Sruthi Vijaya Retnakumar  1 , Jagadeesh Bayry  2
Affiliations

Obesity negatively impacts maintenance of antibody response to COVID-19 vaccines

Camille Chauvin et al. Cell Rep Med. .

Abstract

Severe obesity accelerates the decline of neutralizing antibodies to COVID-19 vaccines contributing to increased risk of hospitalization from breakthrough SARS-CoV-2 infections.1 These findings have repercussion on the vaccination policy for SARS-CoV-2 variants and other infectious diseases like influenza in obese population.

PubMed Disclaimer

Conflict of interest statement

Declaration of interests Authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
A steeper decline in the neutralizing capacity of antibodies in obese compared to lean population after COVID-19 primary and booster vaccination Also, after booster vaccination in obese, anti-spike (S) and anti-RBD antibody (Ab) titers were drastically declined in the long term. Pink, obese; blue, lean; Ag, antigen. Figure created at BioRender.com.
See this image and copyright information in PMC

References

    1. Van Der Klaauw A.A., Horner E.C., Pereyra-Gerber P., Agrawal U., Foster W.S., Spencer S., Vergese B., Smith M., Henning E., Ramsay I.D., et al. Accelerated waning of the humoral response to COVID-19 vaccines in obesity. Nat. Med. 2023;29:1146–1154. doi: 10.1038/s41591-023-02343-2. - DOI - PMC - PubMed
    1. Zhao X., Gang X., He G., Li Z., Lv Y., Han Q., Wang G. Obesity increases the severity and mortality of influenza and COVID-19: a systematic review and meta-analysis. Front. Endocrinol. 2020;11 doi: 10.3389/fendo.2020.595109. - DOI - PMC - PubMed
    1. Eliakim A., Schwindt C., Zaldivar F., Casali P., Cooper D.M. Reduced tetanus antibody titers in overweight children. Autoimmunity. 2006;39:137–141. doi: 10.1080/08916930600597326. - DOI - PMC - PubMed
    1. Sheridan P.A., Paich H.A., Handy J., Karlsson E.A., Hudgens M.G., Sammon A.B., Holland L.A., Weir S., Noah T.L., Beck M.A. Obesity is associated with impaired immune response to influenza vaccination in humans. Int. J. Obes. 2012;36:1072–1077. doi: 10.1038/ijo.2011.208. - DOI - PMC - PubMed
    1. Abd Alhadi M., Friedman L.M., Karlsson E.A., Cohen-Lavi L., Burkovitz A., Schultz-Cherry S., Noah T.L., Weir S.S., Shulman L.M., Beck M.A., Hertz T. Obesity Is associated with an impaired baseline repertoire of anti-influenza virus antibodies. Microbiol. Spectr. 2023;11 doi: 10.1128/spectrum.00010-23. - DOI - PMC - PubMed

Substances

Supplementary concepts