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Comment
. 2023 Jul 18;4(7):101077.
doi: 10.1016/j.xcrm.2023.101077.

Answer to the Hamlet-like dilemma of lipid metabolites causing senile macular degeneration

Valeria Lo Faro  1
Affiliations
Comment

Answer to the Hamlet-like dilemma of lipid metabolites causing senile macular degeneration

Valeria Lo Faro. Cell Rep Med. .

Abstract

In this issue of Cell Reports Medicine, Han et al.1 conducted a multi-ancestry genetic and metabolomic analysis to investigate the causal relationships between age-related macular degeneration and plasma and urine metabolites.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Figures

Figure 1
Figure 1
Summary and prospective of the study Previous studies successfully identified metabolites associated with age-related macular degeneration (AMD), but their causality in a genome-wide approach have not been addressed. Omics technologies, such as genomics and metabolomics, contribute to providing a more holistic view of the pathological processes. The integrative multi-omics approach that combined multi-ancestry metabolomics data (collected from plasma and urine samples) with genomics data, followed by bidirectional Mendelian randomization analyses, provided further biological insights into the causative role of lipid metabolites (i.e., glycerophospholipids, which are also found in biological membranes and lipoproteins). If further validated as AMD biomarkers, lipid metabolites will improve the detection of the disease. Figure created with BioRender.com.
See this image and copyright information in PMC

Comment on

References

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Supplementary concepts