Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Andrada Turcas¹, Sarah M Kelly², Valérie Bernier-Chastagner³, Stephanie Bolle⁴, Alison Cameron⁵, Coreen Corning⁶, Enrico Clementel⁶, Karin Dieckmann⁷, Raquel Davila Fajardo⁸, Mark N Gaze⁹, Anne Laprie¹⁰, Henriette Magelssen¹¹, Silvia Meroni¹², Emanuele Pignoli¹², Akmal Safwat¹³, Giovanni Scarzello¹⁴, James Talbot¹⁵, Beate Timmermann¹⁶, Tom Boterberg¹⁷, Henry C Mandeville¹⁵

Affiliations

¹ The European Society for Paediatric Oncology (SIOP Europe), Brussels, Belgium; The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium; Oncology Department, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania; Radiotherapy Department, Oncology Institute "Prof. Dr. Ion Chiricuta" Cluj-Napoca, Romania. Electronic address: andrada.turcas@iocn.ro.
² The European Society for Paediatric Oncology (SIOP Europe), Brussels, Belgium; The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
³ Department of Radiation Oncology, Institut de Cancérologie de Lorraine, Nancy, France.
⁴ Department of Radiation Oncology, Gustave Roussy, Paris Saclay University, Villejuif, France.
⁵ Bristol Haematology and Oncology Centre, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
⁶ The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium.
⁷ Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Medical University of Vienna, Vienna, Austria; Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria.
⁸ Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
⁹ Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.
¹⁰ Radiation Oncology Department, Institut Claudius Regaud- Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
¹¹ Department of Oncology, Oslo University Hospital, Oslo, Norway.
¹² Medical Physics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
¹³ Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
¹⁴ Radiation Therapy Department, Veneto Institute of Oncology IRCCS, Padua, Italy.
¹⁵ The Royal Marsden Hospital and Institute of Cancer Research, Sutton, UK.
¹⁶ Department of Particle Therapy, University Hospital Essen, West German Proton Therapy Centre Essen (WPE), West German Cancer Center (WTZ), Germany.
¹⁷ Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.

PMID: 37468069
DOI: 10.1016/j.radonc.2023.109810

Free article

Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Andrada Turcas et al. Radiother Oncol. 2023 Oct.

Free article

. 2023 Oct:187:109810.

doi: 10.1016/j.radonc.2023.109810. Epub 2023 Jul 17.

Authors

Affiliations

¹ The European Society for Paediatric Oncology (SIOP Europe), Brussels, Belgium; The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium; Oncology Department, University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Romania; Radiotherapy Department, Oncology Institute "Prof. Dr. Ion Chiricuta" Cluj-Napoca, Romania. Electronic address: andrada.turcas@iocn.ro.
² The European Society for Paediatric Oncology (SIOP Europe), Brussels, Belgium; The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium; Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
³ Department of Radiation Oncology, Institut de Cancérologie de Lorraine, Nancy, France.
⁴ Department of Radiation Oncology, Gustave Roussy, Paris Saclay University, Villejuif, France.
⁵ Bristol Haematology and Oncology Centre, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
⁶ The European Organisation for Research and Treatment of Cancer (EORTC) Headquarters, Brussels, Belgium.
⁷ Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Medical University of Vienna, Vienna, Austria; Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria.
⁸ Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
⁹ Department of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.
¹⁰ Radiation Oncology Department, Institut Claudius Regaud- Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France.
¹¹ Department of Oncology, Oslo University Hospital, Oslo, Norway.
¹² Medical Physics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
¹³ Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark.
¹⁴ Radiation Therapy Department, Veneto Institute of Oncology IRCCS, Padua, Italy.
¹⁵ The Royal Marsden Hospital and Institute of Cancer Research, Sutton, UK.
¹⁶ Department of Particle Therapy, University Hospital Essen, West German Proton Therapy Centre Essen (WPE), West German Cancer Center (WTZ), Germany.
¹⁷ Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.

PMID: 37468069
DOI: 10.1016/j.radonc.2023.109810

Abstract

Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.

Keywords: Clinical trial; Pediatrics; Quality assurance; Radiotherapy; Vertebrae.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Affiliations

Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources