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Comment
. 2023 Sep;33(9):729-731.
doi: 10.1016/j.tcb.2023.07.001. Epub 2023 Jul 18.

'Yapping' with extracellular vesicles in fatty liver metastasis

Ramaroson Andriantsitohaina  1 , M Carmen Martinez  2
Affiliations
Comment

'Yapping' with extracellular vesicles in fatty liver metastasis

Ramaroson Andriantsitohaina et al. Trends Cell Biol. 2023 Sep.

Abstract

Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). A recent study by Wang et al. has deciphered unprecedented prometastatic and immunosuppressive properties of the tumor microenvironment (TME) mediated by hepatocyte-derived extracellular vesicles (EVs) in fatty liver, paving the way for therapeutic innovations to treat patients with CRC and liver metastasis.

Keywords: colorectal cancer; extracellular vesicles; liver metastasis; tumor environment.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

Comment on

  • Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment.
    Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang YM, Matsuda M, Reolizo L, Tsuchiya T, Billet S, Gangi A, Noureddin M, Falk BA, Kim S, Fan W, Tighiouart M, You S, Lewis MS, Pandol SJ, Di Vizio D, Merchant A, Posadas EM, Bhowmick NA, Lu SC, Seki E. Wang Z, et al. Cell Metab. 2023 Jul 11;35(7):1209-1226.e13. doi: 10.1016/j.cmet.2023.04.013. Epub 2023 May 11. Cell Metab. 2023. PMID: 37172577 Free PMC article.

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