The Aging Biomarker Consortium represents a new era for aging research in China

doi:10.1038/s41591-023-02444-y

. 2023 Sep;29(9):2162-2165.

doi: 10.1038/s41591-023-02444-y.

The Aging Biomarker Consortium represents a new era for aging research in China

Jie Ren^#^{1

2

3

4}, Moshi Song^#^{1

3

4

5}, Weiqi Zhang^#^{2

3

4}, Jian-Ping Cai⁶, Feng Cao⁷, Zhongwei Cao⁸, Piu Chan⁹, Chang Chen¹⁰, Guobing Chen^{11

12}, Hou-Zao Chen¹³, Jun Chen¹⁴, Xiao-Chun Chen¹⁵, Weimin Ci², Bi-Sen Ding⁸, Qiurong Ding¹⁶, Feng Gao¹⁷, Shaorong Gao¹⁸, Jing-Dong J Han¹⁹, Qi-Yang He²⁰, Kai Huang^{21

22

23

24}, Zhenyu Ju²⁵, Qing-Peng Kong^{26

27}, Ji Li^{28

29

30}, Jian Li⁶, Jingyi Li^{1

3

5}, Xin Li^{3

4

5

31}, Baohua Liu³², Feng Liu³³, Jun-Ping Liu³⁴, Lin Liu^{35

36

37

38}, Qiang Liu³⁹, Qiang Liu^{40

41}, Xingguo Liu⁴², Yong Liu⁴³, Xianghang Luo⁴⁴, Shuai Ma^{1

3

4}, Xinran Ma⁴⁵, Zhiyong Mao⁴⁶, Jing Nie⁴⁷, Yaojin Peng^{3

5

31}, Jing Qu^{3

4

5

31}, Ruibao Ren^{48

49}, Weihong Song⁵⁰, Zhou Songyang^{51

52}, Liang Sun⁶, Yi Eve Sun⁵³, Yu Sun⁵⁴, Mei Tian⁵⁵, Xiao-Li Tian⁵⁶, Ye Tian^{3

57}, Jianwei Wang⁵⁸, Shusen Wang⁵⁹, Si Wang^{60

61

62}, Wengong Wang⁶³, Xia Wang⁵⁸, Xiaoning Wang⁶⁴, Yan-Jiang Wang⁶⁵, Yunfang Wang⁶⁶, Catherine C L Wong⁶⁷, Andy Peng Xiang^{68

69}, Yichuan Xiao⁵⁴, Zhi-Xiong Xiao⁷⁰, Zhengwei Xie^{71

72}, Wei Xiong⁷³, Daichao Xu⁷⁴, Ze Yang⁶, Jing Ye^{75

76}, Wei Yu⁷⁷, Rui Yue⁷⁸, Cuntai Zhang^{79

80}, Hongbo Zhang^{68

81

82}, Liang Zhang^{4

54}, Xinchao Zhang⁸³, Yong Zhang^{84

85}, Yun-Wu Zhang⁸⁶, Zhuohua Zhang^{87

88}, Tongbiao Zhao^{3

4

5

31}, Yuzheng Zhao^{89

90}, Zhongjun Zhou⁹¹, Dahai Zhu^{84

85}, Weiguo Zou⁹², Gang Pei⁹³, Guang-Hui Liu^{94

95

96

97

98}

Affiliations

¹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
² CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
³ University of Chinese Academy of Sciences, Beijing, China.
⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
⁶ The NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, China.
⁷ Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
⁸ State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China.
⁹ National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China.
¹⁰ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
¹¹ Department of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou, China.
¹² Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, China.
¹³ Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁴ Peking University Research Center on Aging, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Department of Integration of Chinese and Western Medicine, School of Basic Medical Science, Peking University, Beijing, China.
¹⁵ Department of Neurology, Union Hospital of Fujian Medical University, Fuzhou, China.
¹⁶ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
¹⁷ Key Laboratory of Aerospace Medicine, Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, China.
¹⁸ Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
¹⁹ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Peking University, Beijing, China.
²⁰ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
²¹ Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
²² Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, China.
²³ Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, China.
²⁴ Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
²⁵ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Ageing and Regenerative Medicine, Jinan University, Guangzhou, China.
²⁶ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China.
²⁷ State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
²⁸ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
²⁹ Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.
³⁰ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
³¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
³² School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, China.
³³ Metabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, China.
³⁴ Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou, China.
³⁵ Department of Genetics and Cell Biology, College of Life Science, Nankai University, Tianjin, China.
³⁶ Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
³⁷ Institute of Translational Medicine, Tianjin Union Medical Center, Nankai University, Tianjin, China.
³⁸ State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.
³⁹ Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
⁴⁰ Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
⁴¹ Tianjin Institute of Immunology, Tianjin Medical University, Tianjin, China.
⁴² CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, China.
⁴³ College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.
⁴⁴ Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
⁴⁵ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
⁴⁶ Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
⁴⁷ The State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
⁴⁸ Shanghai Institute of Hematology, State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine (Shanghai), International Center for Aging and Cancer, Collaborative Innovation Center of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴⁹ International Center for Aging and Cancer, Hainan Medical University, Haikou, China.
⁵⁰ Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, China.
⁵¹ MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, School of Life Sciences, Institute of Healthy Aging Research, Sun Yat-sen University, Guangzhou, China.
⁵² Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
⁵³ Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
⁵⁴ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
⁵⁵ Human Phenome Institute, Fudan University, Shanghai, China.
⁵⁶ Aging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang, China.
⁵⁷ State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
⁵⁸ School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
⁵⁹ Research Institute of Transplant Medicine, Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, China.
⁶⁰ Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
⁶¹ Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, China.
⁶² Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China.
⁶³ Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
⁶⁴ Institute of Geriatrics, The Second Medical Center, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
⁶⁵ Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
⁶⁶ Hepatobiliary and Pancreatic Center, Medical Research Center, Beijing Tsinghua Changgung Hospital, Beijing, China.
⁶⁷ Clinical Research Institute, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
⁶⁸ Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China.
⁶⁹ National-Local Joint Engineering Research Center for Stem Cells and Regenerative Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
⁷⁰ Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
⁷¹ Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, China.
⁷² Beijing & Qingdao Langu Pharmaceutical R&D Platform, Beijing Gigaceuticals, Beijing, China.
⁷³ Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
⁷⁴ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
⁷⁵ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁷⁶ International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital, Shanghai, China.
⁷⁷ State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.
⁷⁸ Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
⁷⁹ Department of Geriatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁸⁰ Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁸¹ The SYSU-YSG Joint Laboratory for Skin Health Research, Sun Yat-sen University, Guangzhou, China.
⁸² Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
⁸³ Department of Emergency, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
⁸⁴ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China.
⁸⁵ The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
⁸⁶ Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China.
⁸⁷ Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Institute of Molecular Precision Medicine, Xiangya Hospital, Central South University, Changsha, China.
⁸⁸ Department of Neurosciences, Hengyang Medical School, University of South China, Hengyang, China.
⁸⁹ Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
⁹⁰ Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing, China.
⁹¹ School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
⁹² State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
⁹³ Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Biomedicine, The Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai, China.
⁹⁴ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
⁹⁵ University of Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
⁹⁶ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
⁹⁷ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. ghliu@ioz.ac.cn.
⁹⁸ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China. ghliu@ioz.ac.cn.

^# Contributed equally.

PMID: 37468667
DOI: 10.1038/s41591-023-02444-y

The Aging Biomarker Consortium represents a new era for aging research in China

Jie Ren et al. Nat Med. 2023 Sep.

. 2023 Sep;29(9):2162-2165.

doi: 10.1038/s41591-023-02444-y.

Authors

Affiliations

¹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
² CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China.
³ University of Chinese Academy of Sciences, Beijing, China.
⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China.
⁶ The NHC Key Laboratory of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, China.
⁷ Department of Cardiology, The Second Medical Centre, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
⁸ State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, China.
⁹ National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China.
¹⁰ National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
¹¹ Department of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou, China.
¹² Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, Guangzhou, China.
¹³ Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁴ Peking University Research Center on Aging, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Department of Integration of Chinese and Western Medicine, School of Basic Medical Science, Peking University, Beijing, China.
¹⁵ Department of Neurology, Union Hospital of Fujian Medical University, Fuzhou, China.
¹⁶ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
¹⁷ Key Laboratory of Aerospace Medicine, Ministry of Education, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, China.
¹⁸ Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
¹⁹ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Peking University, Beijing, China.
²⁰ Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
²¹ Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
²² Hubei Clinical Research Center of Metabolic and Cardiovascular Disease, Huazhong University of Science and Technology, Wuhan, China.
²³ Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, China.
²⁴ Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
²⁵ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Ageing and Regenerative Medicine, Jinan University, Guangzhou, China.
²⁶ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China.
²⁷ State Key Laboratory of Genetic Resources and Evolution, Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Key Laboratory of Healthy Aging Study, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
²⁸ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
²⁹ Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.
³⁰ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
³¹ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
³² School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, China.
³³ Metabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, China.
³⁴ Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou, China.
³⁵ Department of Genetics and Cell Biology, College of Life Science, Nankai University, Tianjin, China.
³⁶ Haihe Laboratory of Cell Ecosystem, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
³⁷ Institute of Translational Medicine, Tianjin Union Medical Center, Nankai University, Tianjin, China.
³⁸ State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, China.
³⁹ Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
⁴⁰ Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
⁴¹ Tianjin Institute of Immunology, Tianjin Medical University, Tianjin, China.
⁴² CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, China.
⁴³ College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.
⁴⁴ Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, China.
⁴⁵ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
⁴⁶ Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
⁴⁷ The State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
⁴⁸ Shanghai Institute of Hematology, State Key Laboratory for Medical Genomics, National Research Center for Translational Medicine (Shanghai), International Center for Aging and Cancer, Collaborative Innovation Center of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴⁹ International Center for Aging and Cancer, Hainan Medical University, Haikou, China.
⁵⁰ Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Clinical Research Center for Mental Disorders, School of Mental Health and The Affiliated Kangning Hospital, Wenzhou Medical University, Wenzhou, China.
⁵¹ MOE Key Laboratory of Gene Function and Regulation, Guangzhou Key Laboratory of Healthy Aging Research, School of Life Sciences, Institute of Healthy Aging Research, Sun Yat-sen University, Guangzhou, China.
⁵² Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
⁵³ Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
⁵⁴ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
⁵⁵ Human Phenome Institute, Fudan University, Shanghai, China.
⁵⁶ Aging and Vascular Diseases, Human Aging Research Institute and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang, China.
⁵⁷ State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
⁵⁸ School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
⁵⁹ Research Institute of Transplant Medicine, Organ Transplant Center, NHC Key Laboratory for Critical Care Medicine, Tianjin First Central Hospital, Nankai University, Tianjin, China.
⁶⁰ Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
⁶¹ Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing, China.
⁶² Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China.
⁶³ Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
⁶⁴ Institute of Geriatrics, The Second Medical Center, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
⁶⁵ Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
⁶⁶ Hepatobiliary and Pancreatic Center, Medical Research Center, Beijing Tsinghua Changgung Hospital, Beijing, China.
⁶⁷ Clinical Research Institute, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
⁶⁸ Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, China.
⁶⁹ National-Local Joint Engineering Research Center for Stem Cells and Regenerative Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
⁷⁰ Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
⁷¹ Peking University International Cancer Institute, Health Science Center, Peking University, Beijing, China.
⁷² Beijing & Qingdao Langu Pharmaceutical R&D Platform, Beijing Gigaceuticals, Beijing, China.
⁷³ Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Biomedical Sciences and Health Laboratory of Anhui Province, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
⁷⁴ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
⁷⁵ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁷⁶ International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital, Shanghai, China.
⁷⁷ State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, China.
⁷⁸ Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.
⁷⁹ Department of Geriatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁸⁰ Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁸¹ The SYSU-YSG Joint Laboratory for Skin Health Research, Sun Yat-sen University, Guangzhou, China.
⁸² Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
⁸³ Department of Emergency, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
⁸⁴ Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China.
⁸⁵ The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China.
⁸⁶ Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China.
⁸⁷ Key Laboratory of Molecular Precision Medicine of Hunan Province and Center for Medical Genetics, Institute of Molecular Precision Medicine, Xiangya Hospital, Central South University, Changsha, China.
⁸⁸ Department of Neurosciences, Hengyang Medical School, University of South China, Hengyang, China.
⁸⁹ Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.
⁹⁰ Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing, China.
⁹¹ School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
⁹² State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
⁹³ Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-Based Biomedicine, The Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai, China.
⁹⁴ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
⁹⁵ University of Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
⁹⁶ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.
⁹⁷ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, China. ghliu@ioz.ac.cn.
⁹⁸ Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, China. ghliu@ioz.ac.cn.

^# Contributed equally.

PMID: 37468667
DOI: 10.1038/s41591-023-02444-y

No abstract available

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1. Aging Biomarker Consortium et al. Sci. China Life Sci. 66, 893–1066 (2023).
1. Zhang, W. et al. Nat. Rev. Mol. Cell Biol. 21, 137–150 (2020). - DOI - PubMed
1. Cai, Y. et al. Sci. China Life Sci. 65, 2354–2454 (2022). - DOI - PubMed - PMC
1. Lopez-Otin, C. et al. Cell 186, 243–278 (2023). - DOI - PubMed
1. Campisi, J. et al. Nature 571, 183–192 (2019). - DOI - PubMed - PMC

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[1] Aging Biomarker Consortium et al. Sci. China Life Sci. 66, 893–1066 (2023).

[2] Aging Biomarker Consortium et al. Sci. China Life Sci. 66, 893–1066 (2023).

[3] Zhang, W. et al. Nat. Rev. Mol. Cell Biol. 21, 137–150 (2020). - DOI - PubMed

[4] Zhang, W. et al. Nat. Rev. Mol. Cell Biol. 21, 137–150 (2020). - DOI - PubMed

[5] Cai, Y. et al. Sci. China Life Sci. 65, 2354–2454 (2022). - DOI - PubMed - PMC

[6] Cai, Y. et al. Sci. China Life Sci. 65, 2354–2454 (2022). - DOI - PubMed - PMC

[7] Lopez-Otin, C. et al. Cell 186, 243–278 (2023). - DOI - PubMed

[8] Lopez-Otin, C. et al. Cell 186, 243–278 (2023). - DOI - PubMed

[9] Campisi, J. et al. Nature 571, 183–192 (2019). - DOI - PubMed - PMC

[10] Campisi, J. et al. Nature 571, 183–192 (2019). - DOI - PubMed - PMC

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The Aging Biomarker Consortium represents a new era for aging research in China

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