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Comment
. 2023 Sep;22(9):694.
doi: 10.1038/d41573-023-00121-w.

Topoisomerase II inhibitor cures trypanosome infections

Sarah Crunkhorn
Comment

Topoisomerase II inhibitor cures trypanosome infections

Sarah Crunkhorn. Nat Rev Drug Discov. 2023 Sep.
No abstract available

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Comment on

  • Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
    Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, René O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Mäser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT. Rao SPS, et al. Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29. Science. 2023. PMID: 37384702

References

    1. Rao, S. P. S. et al. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science 380, 1349–1356 (2023) - PubMed - DOI

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