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Review
. 2023 Sep;34(3):408-417.
doi: 10.1007/s00335-023-10010-7. Epub 2023 Jul 19.

INFRAFRONTIER: mouse model resources for modelling human diseases

Asrar Ali Khan  1 , Gema Valera Vazquez  2 , Montse Gustems  2 , Rafaele Matteoni  3 , Fei Song  2 , Philipp Gormanns  2 , Sabine Fessele  2 , Michael Raess  2 , Martin Hrabĕ de Angelis  2   4 ; INFRAFRONTIER Consortium
Affiliations
Review

INFRAFRONTIER: mouse model resources for modelling human diseases

Asrar Ali Khan et al. Mamm Genome. 2023 Sep.

Abstract

Over the last decade, INFRAFRONTIER has positioned itself as a world-class Research Infrastructure for the generation, phenotyping, archiving, and distribution of mouse models in Europe. The INFRAFRONTIER network consists of 22 partners from 15 countries, and is continuously enhancing and broadening its portfolio of resources and services that are offered to the research community on a non-profit basis. By bringing together European rodent model expertise and providing valuable disease model services to the biomedical research community, INFRAFRONTIER strives to push the accessibility of cutting-edge human disease modelling technologies across the European research landscape. This article highlights the latest INFRAFRONTIER developments and informs the research community about its extensively utilised services, resources, and technical developments, specifically the intricacies of the INFRAFRONTIER database, use of Curated Disease Models, overview of the INFRAFRONTIER Cancer and Rare Disease resources, and information about its main state-of-the-art services.

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Conflict of interest statement

Authors disclose that there are no financial or non-financial interests that are directly or indirectly related to the work submitted for publication.

Disclosure of potential conflicts of interest: The authors declare that there are no potential conflicts of interests that are directly or indirectly related to this publication.

Figures

Fig. 1
Fig. 1
A simplified schematic representation of the data processes in the INFRAFRONTIER database that includes sources of model data, the different kinds of stored information, curation and enrichment activities, and channels for data dissemination. DO: Disease Ontology; EMMA: European Mouse Mutant Archive; IMPC: International Mouse Phenotyping Consortium; IMSR: International Mouse Strain Resource; IPR: Intellectual Property Rights; MGI: Mouse Genome Informatics; MP: Mammalian Phenotype ontology term
Fig. 2
Fig. 2
Simple overview of the late onset phenotyping carried out in INFRAFRONTIER Mouse Clinics. This phenotyping pipeline, based on the IMPC pipeline, involves standardised procedures and tests to compare juvenile and adult cohorts of mouse strains to investigate ageing-related disorders. CSD: Combined Modified SHIRPA and Dysmorphology; ECG: Electrocardiogram; Echo: Echocardiogram
See this image and copyright information in PMC

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