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. 2023 Nov;101(11):1711-1727.
doi: 10.1002/jnr.25230. Epub 2023 Jul 19.

Altered dynamic functional network connectivity and topological organization variance in patients with white matter hyperintensities

Chaojuan Huang  1 , Xia Zhou  1 , Mengmeng Ren  1 , Wei Zhang  1 , Ke Wan  1 , Jiabin Yin  1 , Mingxu Li  1 , Zhiwei Li  1 , Xiaoqun Zhu  1 , Zhongwu Sun  1
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Altered dynamic functional network connectivity and topological organization variance in patients with white matter hyperintensities

Chaojuan Huang et al. J Neurosci Res. 2023 Nov.

Abstract

White matter hyperintensities (WMHs) of presumed vascular origin are important imaging biomarkers of cerebral small vessel disease (CSVD). Previous studies have verified abnormal functional brain networks in CSVD. However, most of these studies rely on static functional connectivity, and only a few focus on the varying severity of the WMHs. Hence, our study primarily explored the disrupted dynamic functional network connectivity (dFNC) and topological organization variance in patients with WMHs. This study included 38 patients with moderate WMHs, 47 with severe WMHs, and 68 healthy controls (HCs). Ten independent components were chosen using independent component analysis based on resting-state functional magnetic resonance imaging. The dFNC of each participant was estimated using sliding windows and k-means clustering. We identified three reproducible dFNC states. Among them, patients with WMHs had a significantly higher occurrence in the sparsely connected State 1, but a lower occurrence and shorter duration in the positive and stronger connected State 3. Regarding topological organization variance, patients with WMHs showed higher variance in local efficiency but not global efficiency compared to HCs. Among the WMH subgroups, patients with severe WMHs showed similar but more obvious alterations than those with moderate WMHs. These altered network characteristics indicated an imbalance between the functional segregation and integration of brain networks, which was correlated with global cognition, memory, executive functions, and visuospatial abilities. Our study confirmed aberrant dFNC state metrics and topological organization variance in patients with moderate-to-severe WMHs; thus, it might provide a new pathway for exploring the pathogenesis of cognitive impairment.

Keywords: cognition; dynamic functional network connectivity; topological organization; white matter hyperintensities.

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