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Review
. 2024 Jan;79(1):26-36.
doi: 10.1111/all.15818. Epub 2023 Jul 19.

Mind and skin: Exploring the links between inflammation, sleep disturbance and neurocognitive function in patients with atopic dermatitis

Shona Cameron  1 , Ali Donnelly  1 , Conor Broderick  1 , Tomoki Arichi  2 , Ullrich Bartsch  3   4 , Paola Dazzan  5 , Jesper Elberling  6 , Emma Godfrey  7 , Paul Gringras  8 , Lauren C Heathcote  7 , Desaline Joseph  8 , Tobias C Wood  9 , Carmine Pariante  4 , Katya Rubia  4 , Carsten Flohr  1
Affiliations
Review

Mind and skin: Exploring the links between inflammation, sleep disturbance and neurocognitive function in patients with atopic dermatitis

Shona Cameron et al. Allergy. 2024 Jan.

Erratum in

Abstract

Atopic dermatitis (AD) is a chronic, pruritic and inflammatory, dry skin condition with many known comorbidities. These include airway disease, food allergies, atopic eye disease and autoimmune conditions. Furthermore, there is often significant sleep disturbance as well as increased psychological distress and mental health problems. Severe AD therefore often has a significant impact on the quality of life of both patients and their families. In this review we discuss recent findings on the putative links between AD, its association with itch, sleep disturbance and neuropsychiatric morbidity, including the role of inflammation in these conditions. Itch was thought to predominantly drive sleep disruption in AD. We now understand changes in sleep influence immune cell distribution and the associated inflammatory cytokines, which suggests a bidirectional relationship between AD and sleep. We also increasingly recognize inflammation as a key driver in psychological symptoms and disorders. The link between cutaneous, systemic and possible brain inflammation could at least in part be driven by the sleep deprivation and itch-driven neuronal proliferation seen in AD.

Keywords: atopic dermatitis; cognitive dysfunction; inflammation; quality-of-life; sleep disruption.

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References

REFERENCES

    1. Larsen FS, Hanifin JM. Epidemiology of atopic dermatitis. Immunol Allergy Clin. 2002;22(1):1-24.
    1. de Lusignan S, Alexander H, Broderick C, et al. The epidemiology of eczema in children and adults in England: a population-based study using primary care data. Clin Exp Allergy. 2021;51(3):471-482.
    1. de Lusignan S, Alexander H, Broderick C, et al. Atopic dermatitis and risk of autoimmune conditions: population-based cohort study. J Allergy Clin Immunol. 2022;150:709-713.
    1. Yang EJ, Beck KM, Sekhon S, Bhutani T, Koo J. The impact of pediatric atopic dermatitis on families: a review. Pediatr Dermatol. 2019;36(1):66-71.
    1. Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA. The burden of atopic dermatitis: summary of a report for the National Eczema Association. J Invest Dermatol. 2017;137(1):26-30.