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. 2023 Jul-Aug;25(4):157-162.
doi: 10.7224/1537-2073.2021-030. Epub 2023 Mar 8.

Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis

Rogier J Scherder  1 , M J van Dorp  2 , A J Prins  3 , C van Klaveren  1 , I Cornelisz  1 , J Killestein  4 , Henry C Weinstein  5
Affiliations

Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis

Rogier J Scherder et al. Int J MS Care. 2023 Jul-Aug.

Abstract

Background: Although the relationships among physical disability, mood disorders, and pain are well described in multiple sclerosis (MS), little is known about whether those symptoms are associated with sleep disturbances.

Methods: Forty-six patients with MS experiencing pain participated. Sleep was indirectly measured by assessing rest-activity rhythm via actigraphy: interdaily stability, intradaily variability, and relative amplitude. Pain was assessed using visual and verbal analog scales, mood by the Beck Depression Inventory and Symptom Checklist-90, and physical disability by the Expanded Disability Status Scale.

Results: Incorporating mood, pain, and physical disability into 1 regression model resulted in a significant association with interdaily stability.

Conclusions: Compared with intradaily variability and relative amplitude, interdaily stability seems to be the most vulnerable actigraphy variable for mood disturbances, pain, and physical disabilities.

Keywords: disability; mood; multiple sclerosis; pain; rest-activity rhythm.

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Conflict of interest statement

FINANCIAL DISCLOSURES: The authors declare no conflicts of interest.

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