Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jun 28;7(3):195-202.
doi: 10.33546/bnj.1337. eCollection 2021.

Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand

Apichaya Thontham  1 , Rapin Polsook  1
Affiliations

Symptom experience of adverse drug reaction among male and female patients with newly diagnosed pulmonary tuberculosis in Thailand

Apichaya Thontham et al. Belitung Nurs J. .

Abstract

Background: Patients with newly diagnosed pulmonary tuberculosis often suffer from adverse drug reaction symptoms, which leads to the automatic discontinuation of anti-tuberculosis drugs. Thus, understanding symptom experience of adverse drug reactions is necessary.

Objective: This study aimed to examine differences in symptoms experienced in four dimensions: presence, frequency, severity, and distress of adverse drug reactions, between male and female patients.

Methods: This was a quantitative survey with a cross-sectional design, with data collected between January and April 2020. A total of 394 patients with newly diagnosed pulmonary tuberculosis was selected through a purposive sampling technique. The symptom experiences of adverse drug reactions were measured using a validated instrument. Data were analyzed using mean, standard deviation, and independent t-test.

Results: The most commonly reported symptom was itchiness (24.1% in males and 34.9% in females). Vomiting occurred as the most frequent symptom among males (x̄ ± SD = 2.73 ± .88), and fatigue was found to be the most severe and distressing symptom across male patients (x̄ ± SD = 2.50 ± 1.61 and 2.06 ± 1.30, respectively). In contrast, yellowing of the eyes and skin was most frequent and severe among females (x̄ ± SD = 3.17 ± .75 and 3.83 ± 1.47, respectively). In addition, flu-like symptoms were evaluated as the most distressing symptom for female patients (x̄ ± SD = 2.80 ± 1.09). The symptom burdens of the females ranged significantly and reached higher than those of the male patients at a p-value of .05 (t = 3.33).

Conclusion: Females taking anti-tuberculosis drugs should be carefully monitored to deal with adverse drug reaction symptoms. This finding would help to decrease the severity of disease and improve their quality of life.

Keywords: Thailand; adverse drug reaction; drug-related side effects; nursing; pulmonary tuberculosis; quality of life; symptom experiences.

PubMed Disclaimer

Conflict of interest statement

There are no potential conflicts of interest to declare.

References

    1. Almutary, Hayfa, Bonner, Ann, & Douglas, Clint. (2015). Arabic translation, adaptation and modification of the dialysis symptom index for chronic kidney disease stages four and five. BMC Nephrology, 16(1), 1-8. 10.1186/s12882-015-0036-2 - DOI - PMC - PubMed
    1. Armstrong, Terri S. (2003). Symptoms experience: A concept analysis. Oncology Nursing Forum, 30(4), 601-612. 10.1188/03.ONF.601-606 - DOI - PubMed
    1. Dodd, Marylin, Janson, Susan, Facione, Noreen, Faucett, Julia, Froelicher, Erika S., Humphreys, Janice, … Rankin, Sally. (2001). Advancing the science of symptom management. Journal of Advanced Nursing, 33(5), 668-676. 10.1046/j.1365-2648.2001.01697.x - DOI - PubMed
    1. Fang, Yong, Xiao, Heping, Tang, Shenjie, Liang, Li, Sha, Wei, & Fang, Yuanyuan. (2016). Clinical features and treatment of drug fever caused by anti-tuberculosis drugs. The Clinical Respiratory Journal, 10(4), 449-454. 10.1111/crj.12242 - DOI - PubMed
    1. Fei, Cheah Meng, Zainal, Hadzliana, & Ali, Irfhan Ali Hyder. (2018). Evaluation of adverse reactions Induced by anti-tuberculosis drugs in Hospital Pulau Pinang. The Malaysian Journal of Medical Sciences: MJMS, 25(5), 103-114. 10.21315/mjms2018.25.5.10 - DOI - PMC - PubMed

LinkOut - more resources