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. 2023 Jul 4:14:1169933.
doi: 10.3389/fendo.2023.1169933. eCollection 2023.

Coffee intake and risk of diabetic nephropathy: a Mendelian randomization study

Jiaxi Fang  1   2 , Kai Song  3 , Di Zhang  2 , Yan Liang  2 , Huan Zhao  2 , Juan Jin  4 , Qiang He  4
Affiliations

Coffee intake and risk of diabetic nephropathy: a Mendelian randomization study

Jiaxi Fang et al. Front Endocrinol (Lausanne). .

Erratum in

Abstract

Rationale and objective: A causal relationship concerning coffee intake and diabetic nephropathy (DN) is controversial. We conducted a Mendelian randomization study to assess the causal nature of these associations.

Methods: 40 independent single nucleotide polymorphisms (SNPs) associated with coffee intake were selected from the UK Biobank study. Summary-level data for diabetic nephropathy were obtained from publicly available genome-wide association studies (GWAS) and the FinnGen consortium. Inverse variance weighted (IVW), MR-Egger, and weighted median (WM) methods were used to examine a causal association. Sensitivity analyses included Cochran's Q test, the intercept of MR-Egger, MR-PRESSO, and the Outlier method. Leave-One-Out sensitivity analyses were also conducted to reduce the heterogeneity.

Results: Our current study demonstrated positive associations of genetically predicted coffee intake with diabetic nephropathy (OR=1.939; P = 0.045 and type 2 diabetes with renal complications (OR = 2.787, P= 0.047). These findings were robust across several sensitivity analyses.

Conclusions: This study found a positive correlation between coffee consumption and the risk of diabetic nephropathy using genetic data. For a more accurate and trustworthy conclusion, subgroup analysis on coffee intake, including preparing method, variety of coffee, and quantity, is required.

Keywords: Mendelian randomization; causality; coffee intake; diabetic nephropathy; risk.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Mendelian randomization model and three fundamental assumptions of a Mendelian randomization analysis. SNP, single nucleotide polymorphisms.
Figure 2
Figure 2
The framework of the Mendelian randomization analysis. SNP, single nucleotide polymorphisms.
Figure 3
Figure 3
Causal risk between coffee intake and Diabetic Nephropathy was estimated using conventional inverse variance weighted (IVW) Mendelian randomization analysis, Egger-Mendelian randomization (MR-Egger), and weighted median Mendelian randomization. Forest plot and sensitivity analysis of Mendelian randomization analyses showing the effect of coffee intake on the risk of diabetic nephropathy.
Figure 4
Figure 4
The scatter plot for MR analyses of causal associations between each coffee intake SNP and Diabetic nephropathy (A), type 1 diabetes with renal complications (B), type2 diabetes with renal complications (C), glomerular filtration rate in diabetics (D), urinary albumin-to-creatinine ratio (E).
See this image and copyright information in PMC

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