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Editorial
. 2023 Jun;24(8):435-439.
doi: 10.2217/pgs-2023-0096. Epub 2023 Jul 20.

UGT1A1 genotype-guided dosing of irinotecan: time to prioritize patient safety

Sofía Lj Peeters  1   2 , Maarten J Deenen  1   2 , Anna Mj Thijs  3 , Emma C Hulshof  1   2 , Ron Hj Mathijssen  4 , Hans Gelderblom  5 , Henk-Jan Guchelaar  2 , Jesse J Swen  2
Affiliations
Editorial

UGT1A1 genotype-guided dosing of irinotecan: time to prioritize patient safety

Sofía Lj Peeters et al. Pharmacogenomics. 2023 Jun.

Abstract

Tweetable abstract Pretreatment UGT1A1 genotyping and a 70% irinotecan dose intensity in poor metabolizers is safe, feasible, cost-effective and essential for safe irinotecan treatment in cancer patients. It is time to update guidelines to swiftly enable the implementation of UGT1A1 genotype-guided irinotecan dosing in routine oncology care.

Keywords: PGx; UGT1A1; irinotecan; personalized medicine; pharmacogenetics; pharmacogenomics; precision dosing; pretreatment.

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