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Editorial
. 2024 Jan 1;109(1):13-15.
doi: 10.3324/haematol.2023.283469.

The double-edged sword of adenosine

Isabelle Plo  1 , Iléana Antony-Debré  2
Affiliations
Editorial

The double-edged sword of adenosine

Isabelle Plo et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Extracellular adenosine induces decreased erythropoiesis via adenosine receptors A2BAR and A3AR. While A3AR inhibits erythroid proliferation and differentiation, A2BAR inhibits erythroid maturation with no effect on proliferation. The defective erythropoiesis is due to activation of P53- and caspase 3-dependent apoptosis. Moreover, activation of A3AR decreases erythropoiesis and favors myelopoiesis.
See this image and copyright information in PMC

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References

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