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Editorial
. 2023 Jul 21;133(3):252-254.
doi: 10.1161/CIRCRESAHA.123.323211. Epub 2023 Jul 20.

Cardiac Fibrosis Mitigated by an Endogenous Negative Regulator of HDAC

Michael P Lazaropoulos  1 , John W Elrod  1
Affiliations
Editorial

Cardiac Fibrosis Mitigated by an Endogenous Negative Regulator of HDAC

Michael P Lazaropoulos et al. Circ Res. .
No abstract available

Keywords: Editorials; aging; fibrosis; heart failure; myofibroblast; ubiquitin.

PubMed Disclaimer

Conflict of interest statement

Disclosures None.

Figures

Figure.
Figure.. PDCD5 (programmed cell death 5) mediates a negative feedback loop by HDAC3 (histone deacetylase 3) degradation.
(1) TGFβ (transforming growth factor-β)/SMAD (SMAD family member) signaling drives expression of PDCD5. (2) PDCD5 associates with HDAC3 in the nucleus to (3) promote export from the nucleus for ubiquitination and degradation. With loss of nuclear HDAC3, (4) disinhibited SMAD7 negatively feeds back to reduce/repress myofibroblast gene expression. (5) Previous reports of PDCD5 interacting with p53 may reinforce/promote myofibroblast senescence.
See this image and copyright information in PMC

Comment on

References

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