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Comment
. 2023 Jul 20;62(1):2300995.
doi: 10.1183/13993003.00995-2023. Print 2023 Jul.

Reply: Confounding in Mendelian randomisation studies

Carl J Reynolds  1 , Cosetta Minelli  2
Affiliations
Comment

Reply: Confounding in Mendelian randomisation studies

Carl J Reynolds et al. Eur Respir J. .

Abstract

Mendelian randomisation (MR) overcomes classical confounding issues that beset observational studies. “Horizontal” but not “vertical” pleiotropy can bias MR study findings but we found no evidence that it was present in our MR analysis of GORD on IPF. https://bit.ly/3Jn7aeq

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Conflict of interest statement

Conflict of interest: The authors have no potential conflicts of interest to disclose.

Comment on

References

    1. Reynolds CJ, Del Greco M F, Allen RJ, et al. . The causal relationship between gastro-esophageal reflux disease and idiopathic pulmonary fibrosis: a bidirectional two-sample Mendelian randomization study. Eur Respir J 2023; 61: 2201585. doi:10.1183/13993003.01585-2022 - DOI - PMC - PubMed