EGR2 drives T_H17 cell pathogenicity in autoimmune neuroinflammation

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No authors listed. Nat Immunol. 2023 Aug.

. 2023 Aug;24(8):1230-1231.

doi: 10.1038/s41590-023-01568-0.

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Transcription factor EGR2 controls homing and pathogenicity of T_H17 cells in the central nervous system.
Gao Y, Wang Y, Chauss D, Villarino AV, Link VM, Nagashima H, Spinner CA, Koparde VN, Bouladoux N, Abers MS, Break TJ, Chopp LB, Park JH, Zhu J, Wiest DL, Leonard WJ, Lionakis MS, O'Shea JJ, Afzali B, Belkaid Y, Lazarevic V. Gao Y, et al. Nat Immunol. 2023 Aug;24(8):1331-1344. doi: 10.1038/s41590-023-01553-7. Epub 2023 Jul 13. Nat Immunol. 2023. PMID: 37443284 Free PMC article.

1. Mills, K. H. G. IL-17 and IL-17-producing cells in protection versus pathology. Nat. Rev. Immunol. 23, 38–54 (2023). This review article discusses protective and pathogenic nature of T_H17 cells. - DOI - PubMed
1. Loo, T. T., Gao, Y. & Lazarevic, V. Transcriptional regulation of CD4⁺ T_H cells that mediate tissue inflammation. J. Leukoc. Biol. 104, 1069–1085 (2018). This review discusses how combinatorial expression of transcription factors regulates CD4⁺ T cell function. - DOI - PubMed
1. Cao, Y. et al. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Sci. Transl. Med. 7, 287ra274 (2015). This paper reports that myelin-reactive T cells from patients with MS secrete more proinflammatory cytokines than cells from healthy controls. - DOI
1. Gaublomme, J. T. et al. Single-cell genomics unveils critical regulators of T_H17 cell pathogenicity. Cell 163, 1400–1412 (2015). This paper uses single-cell RNA-seq to identify regulators of T_H17 cell pathogenicity. - DOI - PubMed - PMC
1. Ciofani, M. et al. A validated regulatory network for T_H17 cell specification. Cell 151, 289–303 (2012). This study reports the first comprehensive, validated gene regulatory network for T_H17 cell lineage commitment. - DOI - PubMed - PMC