Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar;72(3):176-182.
doi: 10.1007/s11748-023-01962-3. Epub 2023 Jul 20.

Can modified frailty index predict postoperative complication after lung cancer surgery?

Hironobu Wada  1   2 , Hidemi Suzuki  3 , Yuichi Sakairi  1 , Kazuhisa Tanaka  1 , Yuki Sata  1 , Takahide Toyoda  1 , Terunaga Inage  1 , Yukiko Matsui  1 , Ichiro Yoshino  1   2
Affiliations

Can modified frailty index predict postoperative complication after lung cancer surgery?

Hironobu Wada et al. Gen Thorac Cardiovasc Surg. 2024 Mar.

Abstract

Purpose: The impact of the modified frailty index (mFI) on postoperative complications after lung cancer surgery was investigated.

Methods: Patients who underwent lung cancer surgery in 2017 were included. 30-day postoperative mortality and morbidity were evaluated according to their Clavien-Dindo classification. mFI values are presented as the sum of values of 11 included items. Logistic regression was used to assess the effect of mFI on postoperative severe complication incidence.

Results: Among 190 patients considered, severe postoperative complications (Grade 3 or more) were observed in 30 (16%). No patients died within 30 days of surgery. The incidence of severe complications was 3.6% in patients with mFI of 0, 16.2% in patients with mFI of 1, 23.4% in patients with mFI of 2, and 31.6% in patients with mFI of 3 or more, and was correlated with the grade of mFI. Univariate and multivariate analyses showed that the high mFI was significantly predictive of postoperative complications. Frail patients of mFI ≥ 2 were at 3.0-fold greater risk of severe complications than non-frail patients of mFI 0 or 1.

Conclusion: mFI was associated with morbidity after lung cancer surgery. Preoperative frailty assessment and appropriate intervention to frail patients would be required to improve postoperative outcomes.

Keywords: Frailty; Lung cancer; Postoperative complication; Preoperative assessment.

PubMed Disclaimer

References

    1. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–56. - DOI - PubMed
    1. Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Sci World J. 2001;1:323–36. - DOI
    1. Rockwood K, Mitnitski A. Frailty in relation to the accumulation of deficits. J Gerontol Biol Sci. 2007;62:711–7. - DOI
    1. Velanovich V, Antoine H, Swartz A, Peters D, Rubinfeld I. Accumulating deficits model of frailty and postoperative mortality and morbidity: its application to a national database. J Surg Res. 2013;183:104–10. - DOI - PubMed
    1. Tsiouris A, Hammoud ZT, Velanovich V, Hodari A, Borgi J, Rubinfeld I. A modified frailty index to assess morbidity and mortality after lobectomy. J Surg Res. 2013;183:40–6. - DOI - PubMed

LinkOut - more resources