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Comment
. 2023 Aug;25(8):1085-1086.
doi: 10.1038/s41556-023-01201-0.

Spartin is a receptor for the autophagy of lipid droplets

No authors listed
Comment

Spartin is a receptor for the autophagy of lipid droplets

No authors listed. Nat Cell Biol. 2023 Aug.
No abstract available

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References

    1. Walther, T. C. & Farese, R. V. Lipid droplets and cellular lipid metabolism. Annu. Rev. Biochem. 81, 687–714 (2012). A review on lipid droplet biology. - DOI - PubMed - PMC
    1. Olzmann, J. A. & Carvalho, P. Dynamics and functions of lipid droplets. Nat. Rev. Mol. Cell Biol. 20, 137–155 (2019). A review on lipid droplet biology. - DOI - PubMed - PMC
    1. Singh, R. et al. Autophagy regulates lipid metabolism. Nature 458, 1131–1135 (2009). This paper established that autophagy is important in lipid droplet turnover. - DOI - PubMed - PMC
    1. Patel, H. et al. SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia. Nat. Genet. 31, 347–348 (2002). This paper identified SPG20, the gene encoding spartin, as a cause of hereditary spastic paraplegia. - DOI - PubMed
    1. Edwards, T. L. et al. Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. Biochem. J. 423, 31–39 (2009). This paper provided evidence that spartin might be connected to lipid droplet biology. - DOI - PubMed

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