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. 2023 Jul 20;23(1):330.
doi: 10.1186/s12886-023-03081-2.

Sarcoidosis: experience in a Mexican ophthalmological clinic

Javier Alejandro Salazar-Rodríguez  1 , Diana Sarmiento-Forero  2 , Claudia Hubbe-Tena  2 , Luz-Elena Concha-Del-Rio  3
Affiliations

Sarcoidosis: experience in a Mexican ophthalmological clinic

Javier Alejandro Salazar-Rodríguez et al. BMC Ophthalmol. .

Abstract

Background: Sarcoidosis is an inflammatory disorder in which patients frequently develop ocular manifestations that precede systemic involvement, sometimes it even presents as an ocular isolated form of the disease. The purpose of this study is to report the ocular and systemic manifestations of sarcoidosis in a series of Mexican patients, as there is a low incidence of the disease in this population.

Methods: A retrospective case series of patients with positive classification criteria for sarcoidosis who attended Asociacion Para Evitar la Ceguera en Mexico, IAP between 2011 and 2022. Descriptive statistics were used to report the clinical, laboratory, and imaging findings and treatment. Numerical results were presented using median values and first and third quartiles for distribution.

Results: Fourteen patients were included in this study, 10 of them had definite ocular sarcoidosis (biopsy-proven), 4 had presumed ocular sarcoidosis. The median age of onset was 52 (34; 67), with a predominance of female patients (71.4%). Ten patients (71.4%) debuted with ocular manifestations. The most common forms of ocular involvement were bilateral anterior uveitis (50%) and panuveitis (28.6%). Median follow-up was 24 (13-49) months.

Conclusions: Sarcoidosis is a rare, underdiagnosed condition in Mexico and ocular involvement can be an early manifestation of the disease. Ophthalmologists should be alert to the signs of ocular sarcoidosis and collaborate with a multidisciplinary team to screen for systemic involvement if suspicion is high.

Keywords: México; Ophthalmology; Sarcoidosis; Uveitis.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, et al. The WASOG Sarcoidosis Organ Assessment Instrument: an update of a previous clinical tool. Volume 13. Sarcoidosis Vasculitis And Diffuse Lung Diseases; 2014. - PubMed
    1. Jabs D, Acharya N, Denniston A, Lightman S, McCluskey P, Oden N et al. Classification Criteria for Sarcoidosis-Associated Uveitis. Am J Ophthalmol 2021 Aug 1;228:220–30. - PMC - PubMed
    1. Uveitis: Autoimmunity… and beyond. Autoimmun Rev. 2019 Sep 1;18(9):102351. - PubMed
    1. Carrillo-Pérez DL, Apodaca-Cháveza EI, Carrillo-Maravilla E, Mejía-Ávila M, Hernández-Oropeza JL, Reyes E, et al. Sarcoidosis: a single hospital-based study in a 24-year period. Rev Invest Clin. 2015;67(1):33–8. - PubMed
    1. Jiménez-Balderas FJ, Fernandez-Arrieta G, Camargo-Coronel A, Ake-Uc M, Vazquez-Zaragoza M, Zonana-Nacach A, et al. Uveitis in Adult Patients with Rheumatic Inflammatory Autoimmune Diseases at a tertiary-care hospital in Mexico City. J Rheumatol. 2011 Feb;38(2):325–30. - PubMed