Bioinformatics and Immunohistochemical Analyses Support Preserved Expression of Glial Cell Line-Derived Neurotrophic Factor Receptor RET in Parkinson's

Conor Giles Doran¹, Fionnuala Wilson¹, Susan R Goulding¹, Martina Mazzocchi¹, Louise M Collins^{1

2

3}, Aideen M Sullivan^{1

3}, Gerard W O'Keeffe^{1

3}

Affiliations

¹ Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
² Department of Physiology, University College Cork, Cork, Ireland.
³ Parkinson's Disease Research Centre, University College Cork, Cork, Ireland.

Conor Giles Doran et al. Mov Disord. 2023 Jun.

. 2023 Jun;38(6):1115-1116.

doi: 10.1002/mds.29443.

Conor Giles Doran¹, Fionnuala Wilson¹, Susan R Goulding¹, Martina Mazzocchi¹, Louise M Collins^{1

2

3}, Aideen M Sullivan^{1

3}, Gerard W O'Keeffe^{1

3}

¹ Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
² Department of Physiology, University College Cork, Cork, Ireland.
³ Parkinson's Disease Research Centre, University College Cork, Cork, Ireland.

No abstract available

Comment in

Reply to: "Bioinformatics and Immunohistochemistry Show Preserved Expression of GDNF Receptor RET in Parkinson's".
Whone A. Whone A. Mov Disord. 2023 Jun;38(6):1117-1118. doi: 10.1002/mds.29438. Mov Disord. 2023. PMID: 37475613 No abstract available.

1. Whone A, Luz M, Boca M, et al. Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson's disease. Brain 2019;142(3):512-525. https://doi.org/10.1093/brain/awz023
1. Barker RA, Bjorklund A, Gash DM, et al. GDNF and Parkinson's disease: where next? A summary from a recent workshop. J Parkinsons Dis 2020;10(3):875-891. https://doi.org/10.3233/JPD-202004
1. Chu Y, Kordower JH. GDNF signaling in subjects with minimal motor deficits and Parkinson's disease. Neurobiol Dis 2021;153:105298. https://doi.org/10.1016/j.nbd.2021.105298
1. Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Bjorklund A. Alpha-synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons. Sci Transl Med 2012;4(163):163ra156. https://doi.org/10.1126/scitranslmed.3004676
1. Goulding SR, Concannon RM, Morales-Prieto N, et al. Growth differentiation factor 5 exerts neuroprotection in an alpha-synuclein rat model of Parkinson's disease. Brain 2021;144(2):e14. https://doi.org/10.1093/brain/awaa367