Osteoarthritis - Insights From Recent Research

Abstract

Osteoarthritis (OA) is the most common form of arthritis and is a growing public health concern in the aging society. In rapidly aging societies such as in Korea, the increasing prevalence of OA may present serious new health issues. There is no treatment for OA that can either prevent or slow the progression of joint damage. For the development of effective therapeutics, precise understating of its pathogenesis is important. In this review, the current evidence of etiopathogenesis of OA is discussed. First, while epidemiologic study of OA are still dominated by reports from Western countries, findings from Korean epidemiologic studies are highlighted. Then, recent progresses in genetics, especially in the field of genome wide association study and mendelian randomization studies, are reviewed with focus on Asian population. Lastly, sex difference in pain etopathogenesis is reviewed. Studies of OA pathogenesis including epidemiology, genetics, animal model and pain signaling will aid in progress towards treatment of OA.

Keywords: Genetics; Osteoarthritis; Pain.

Fig. 1

Overview of steps for conducting OA GWAS. OA: osteoarthritis, GWAS: genomewide association study.

Fig. 2

Anatomical and non-anatomical factors leading to knee pain in OA. OA: osteoarthritis.