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. 2021 Jul 1;28(3):126-132.
doi: 10.4078/jrd.2021.28.3.126.

Neuropathic Pain and its Relationship With Fibromyalgia, Vitamin D Status and Medication Use in Patients With Ankylosing Spondylitis

Sema Mızrak  1 , Mehmet Kırnap  2 , İsa Cüce  2
Affiliations

Neuropathic Pain and its Relationship With Fibromyalgia, Vitamin D Status and Medication Use in Patients With Ankylosing Spondylitis

Sema Mızrak et al. J Rheum Dis. .

Abstract

Objective: To determine the frequency of neuropathic pain (NeP) and potentially related new factors including fibromyalgia, vitamin D and medication use in ankylosing spondylitis (AS) patients.

Methods: In total, 102 patients with AS were prospectively enrolled in this study and evaluated for pain severity (visual analog scale, VAS), disease activity (the Bath Ankylosing Spondylitis Disease Activity Index, BASDAI), fibromyalgia and current medication use The presence of NeP was also assessed using the painDETECT questionnaire Blood samples were taken from all patients to analyze serum 25-hydroxyvitamin D and inflammatory marker levels.

Results: NeP component 32 (21 [20.6%]; clearly NeP and 11 [10.8%]; mixed NeP) was present in patients with AS Compared to those without NeP, they had significantly higher VAS and BASDAI scores (p=0.022 and 0.003, respectively) In addition, there was a highly significant difference of frequency of fibromyalgia between patients with and without NeP (50.0% vs 5.7%, p<0.001) Vitamin D status and medication use were comparable for patients with and without NeP Logistic regression analysis revealed that only fibromyalgia was a significant predictor of NeP.

Conclusion: This study confirmed that about one-third of AS patients have the NeP component In addition, NeP was found to be associated with the frequency of fibromyalgia However, no relation was found between NeP and vitamin D status and medication use in AS.

Keywords: Ankylosing spondylitis; Fibromyalgia; Neuropathic pain; Vitamin D.

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Conflict of interest statement

CONFLICT OF INTEREST No potential conflict of interest relevant to this article was reported.

References

    1. Carli L, Calabresi E, Governato G, Braun J. One year in review 2018: axial spondyloarthritis. Clin Exp Rheumatol. 2019;37:889–98. - PubMed
    1. Kiltz U, Baraliakos X, Regel A, Bühring B, Braun J. Causes of pain in patients with axial spondyloarthritis. Clin Exp Rheumatol. 2017;35 Suppl 107:102–7. - PubMed
    1. Geler-Külcü D, Batıbay S, Öztürk G, Mesci N. The association of neuropathic pain and disease activity, functional level, and quality of life in patients with ankylosing spondylitis: a cross-sectional study. Turk J Med Sci. 2018;48:257–65. doi: 10.3906/sag-1707-147. - DOI - PubMed
    1. Gok K, Cengiz G, Erol K, Ozgocmen S. Neuropathic pain component in axial spondyloarthritis and the influence on disease burden. J Clin Rheumatol. 2018;24:324–7. doi: 10.1097/RHU.0000000000000711. - DOI - PubMed
    1. Choi JH, Lee SH, Kim HR, Lee KA. Association of neuropathic-like pain characteristics with clinical and radiographic features in patients with ankylosing spondylitis. Clin Rheumatol. 2018;37:3077–86. doi: 10.1007/s10067-018-4125-z. - DOI - PubMed

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