Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023;5(2):22-31.
doi: 10.33696/immunology.5.163.

IL-1 in Abdominal Aortic Aneurysms

Jessica Millar  1 , Elias Nasser  2 , Gorav Ailawadi  2   3 , Morgan Salmon  2   3
Affiliations

IL-1 in Abdominal Aortic Aneurysms

Jessica Millar et al. J Cell Immunol. 2023.

Abstract

Abdominal Aortic Aneurysms (AAA) remain a clinically devastating disease with no effective medical treatment therapy. AAAs are characterized by immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. Interleukin-1 (IL-1) has been shown to play role in AAA associated inflammation through immune cell recruitment and activation, endothelial dysfunction, production of reactive oxygen species (ROS), and regulation of transcription factors of additional inflammatory mediators. In this review, we will discuss the principles of IL-1 signaling, its role in AAA specific inflammation, and regulators of IL-1 signaling. Additionally, we will discuss the influence of genetic and pharmacological inhibitors of IL-1 on experimental AAAs. Evidence suggests that IL-1 may prove to be a potential therapeutic target in the management of AAA disease.

Keywords: AAA; Anakinra; IL-1α; IL-1β.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Model of Extracellular Functions of IL-1 in Aortic Aneurysm Formation.
Figure 2.
Figure 2.
Model of Intracellular functions of IL-1 signaling in Aortic Aneurysm Formation.
See this image and copyright information in PMC

References

    1. Lindeman JH, Matsumura JS. Pharmacologic Management of Aneurysms. Circulation Research. 2019. Feb 15;124(4):631–46. - PMC - PubMed
    1. Kent KC. Abdominal aortic aneurysms. New England Journal of Medicine. 2014. Nov 27;371(22):2101–8. - PubMed
    1. Salmon M NADPH Oxidases in Aortic Aneurysms. Antioxidants. 2022;11:1830. - PMC - PubMed
    1. Kent KC, Zwolak RM, Egorova NN, Riles TS, Manganaro A, Moskowitz AJ, et al. Analysis of Risk Factors for Abdominal Aortic Aneurysm in a Cohort of more than 3 million individuals. Journal of Vascular Surgery. 52:539–548. - PubMed
    1. Thompson RW, Geraghty PJ, Lee JK. Abdominal Aortic Aneurysms: Basic Mechanisms and Clinical Implications. Current Problems in Surgery. 2002. Feb 1;39(2):110–230. - PubMed

LinkOut - more resources