Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2023 Jun;53(3):780-790.
doi: 10.55730/1300-0144.5641. Epub 2023 Jun 19.

Multidrug resistance in pathogens of community-acquired urinary tract infections in Turkey: a multicentre prospective observational study

İrfan Şencan  1 , Oğuz Karabay  2 , Fatma Aybala Altay  3 , Serap Süzük Yıldız  4 , Hüsniye Şimşek  4 , Melih Gaffar Gözükara  5 , Semanur Kuzi  6 , Gülden Eser Karlıdağ  7 , Şafak Kaya  8 , Gülnur Kul  9 , Emine Türkoğlu  10 , Büşra Ergüt Sezer  11 , Nesibe Korkmaz  12 , Sibel Yıldız Kaya  13 , Merve Sefa Sayar  14 , Dilek Bulut  1 , Fethiye Akgül  15 , Yasemin Çağ  16 , Canan Ağalar  17 , Zehra Beştepe Dursun  18 , Meltem Taşbakan  19 , Sabire Şöhret Aydemir  20 , Derya Seyman  21 , Mustafa Yıldırım  22 , Zafer Habip  23 , Nilgün Altın  1 , Hanife Uzar  24 , Begüm Bektaş  25 , Derya Öztürk Engin  25 , Hüseyin Aytaç Erdem  19 , Serkan Sürme  26
Affiliations
Observational Study

Multidrug resistance in pathogens of community-acquired urinary tract infections in Turkey: a multicentre prospective observational study

İrfan Şencan et al. Turk J Med Sci. 2023 Jun.

Abstract

Background: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options.

Methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolates of 20 centres from 12 different NUTS regions between March 2019 and March 2020 were analysed.

Results: Of the 1588 culture growths, 1269 (79. 9%) were Escherichia coli and 152 (9.6%) were Klebsiella spp. Male sex, advancedage, and having two or more risk factors showed a statistically significant relation with MDR existence (p < 0.001, p: 0.014, p < 0.001, respectively) that increasing number of risk factors or degree of advancing in age directly affects the number of antibiotic groups detected to have resistance by pathogens. In total, MDR isolates corresponded to 36.1% of our CAUTI samples; MDR existence was 35.7% in E. coli isolates and 57.2% in Klebsiella spp. isolates. Our results did not show an association between resistance or MDR occurrence rates and NUTS regions.

Discussion: The necessity of urine culture in outpatient clinics should be taken into consideration, at least after evaluating risk factorsfor antibacterial resistance individually. Community-acquired UTIs should be followed up time- and region-dependently. Antibiotic stewardship programmes should be more widely and effectively administrated.

Keywords: Community-acquired infection; multidrug resistance; quinolone resistance; urinary tract infections.

PubMed Disclaimer

Figures

Figure
Figure
Flow chart of the study.
See this image and copyright information in PMC

References

    1. Foxman B. The epidemiology of urinary tract infection. Nature Reviews Urology. 2010;7(12):653–660. doi: 10.1038/nrurol.2010.190. - DOI - PubMed
    1. Lee DS, Lee SJ, Choe HS. Community-Acquired Urinary Tract Infection by Escherichia coli in the Era of Antibiotic Resistance. Biomed Research International. 2018;2018:7656752. doi: 10.1155/2018/7656752. - DOI - PMC - PubMed
    1. Wright SW, Wrenn KD, Haynes ML. Trimethoprim-sulfamethoxazole resistance among urinary coliform isolates. Journal of General Internal Medicine. 1999;14(10):606–609. doi: 10.1046/j.1525-1497.1999.10128.x. - DOI - PMC - PubMed
    1. Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, et al. Infectious Diseases Society of America; European Society for Microbiology and Infectious Diseases. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clinical Infectious Diseases. 2011;52(5):e103–120. doi: 10.1093/cid/ciq257. - DOI - PubMed
    1. Pappas PG. Laboratory in the diagnosis and management of urinary tract infections. Medical Clinics of North America. 1991;75(2):313–325. doi: 10.1016/s0025-7125(16)30456-4. - DOI - PubMed

Publication types

MeSH terms

Substances