Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2023 Nov-Dec;64(11):1782-1791.
doi: 10.1080/10428194.2023.2235043. Epub 2023 Jul 21.

Clinical features and prognostic outcomes of angioimmunoblastic T cell lymphoma in an Asian multicenter study

Esther Wei Yin Chang  1   2   3 , Valerie Shiwen Yang  1   2   4   3 , Shin Yeu Ong  2   5 , Hilda Xueqi Kang  4 , Boon Yee Lim  6 , Sanjay de Mel  7 , Esther Ka Yan Ng  7 , Michelle Limei Poon  7 , Ya Hwee Tan  1   2 , Jianbang Chiang  1   2 , Eileen Poon  1   2   3 , Nagavalli Somasundaram  1   2   3 , Mohamad Farid  1   2   3 , Tiffany Tang  1   2 , Miriam Tao  1   2   3 , Lay Poh Khoo  1 , Chee Leong Cheng  8 , Dachuan Huang  3   9 , Choon Kiat Ong  3   9 , Soon Thye Lim  1   2   3 , Jason Yongsheng Chan  1   2   3   6
Affiliations
Free article
Multicenter Study

Clinical features and prognostic outcomes of angioimmunoblastic T cell lymphoma in an Asian multicenter study

Esther Wei Yin Chang et al. Leuk Lymphoma. 2023 Nov-Dec.
Free article

Abstract

In our Asian multicenter retrospective study, we investigated the clinical prognostic factors affecting the outcomes of AITL patients and identified a novel prognostic index relevant in the Asian context. In our 174-patient cohort, the median PFS and OS was 1.8 years and 5.6 years respectively. Age > 60, bone marrow involvement, total white cell count >12 × 109/L and raised serum lactate dehydrogenase were associated with poorer PFS and OS in multivariate analyses. This allowed for a prognostic index (AITL-PI) differentiating patients into low (0-1 factors, n = 64), moderate (2 factors, n = 59) and high-risk (3-4 factors, n = 49) subgroups with 5-year OS of 84.0%, 44.0% and 28.0% respectively (p < 0.0001). POD24 proved to be strongly prognostic (5-year OS 24% vs 89%, p < 0.0001). Exploratory gene expression studies were performed and disparate immune cell profiles and cell signaling signatures were seen in the low risk group as compared to the intermediate and high risk groups.

Keywords: Angioimmunoblastic T cell lymphoma; T follicular helper cell lymphoma; gene expression analysis; molecular genetics; prognostication.

PubMed Disclaimer

Publication types

LinkOut - more resources