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. 2023 Sep:145:106033.
doi: 10.1016/j.jmbbm.2023.106033. Epub 2023 Jul 17.

Synthesis of chitosan based reduced graphene oxide-CeO2 nanocomposites for drug delivery and antibacterial applications

Anandhavelu Sanmugam  1 , S Abbishek  2 , S Logesh Kumar  3 , Ananda Babu Sairam  4 , Vishnu Vardhan Palem  5 , Raju Suresh Kumar  6 , Abdulrahman I Almansour  6 , Natarajan Arumugam  6 , Dhanasekaran Vikraman  7
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Synthesis of chitosan based reduced graphene oxide-CeO2 nanocomposites for drug delivery and antibacterial applications

Anandhavelu Sanmugam et al. J Mech Behav Biomed Mater. 2023 Sep.

Abstract

In this study, the unique characteristics of chitosan, reduced graphene oxide (rGO) and cerium oxide (CeO2) based hybrid bionano-composites make a carrier for various drug delivery and antimicrobial applications. The recent literatures shown that addition of biopolymers to rGO and CeO2 based nanocomposites exhibit excellent performance in design and development of biosensors, wound dressings, electrodes, microfluidic chips, drug delivery systems and energy storage applications. Chitosan (CS), reduced graphene oxide (rGO) mixed with cerium oxide (CeO2) to form CS-rGO and CS-rGO-CeO2 hybrid bionano-composites using precipitation method. The physiochemical characterization of casted nanocomposite sheet was done using FTIR, XRD, UV-Vis spectrum, SEM and TGA. The XRD results of CS-rGO-CeO2 revealed that the nanoparticle was found to be crystalline structure. FTIR revealed that nitrogen functionalities of CS interacted with rGO-CeO2 to form hybrid nanocomposites. The thermal gravimetric analysis (TGA) showed that the CS-rGO-CeO2 has better thermal stability up to 550 °C. The SEM confirms the surface morphology of CS-rGO-CeO2 has large surface area with smooth surface. Moreover, the antibacterial properties of nanocomposites exhibit excellent zone of inhibition against Staphylococcus aureus and Escherichia coli. The NIH3T3 cell line evaluations showed superior cell adhesion on hybrid nanocomposites. Hence bionano-composite based on CS, rGO and CeO2 are potential biomaterials for drug delivery and antibacterial applications.

Keywords: Antibacterial; Cerium Oxide; Chitosan; Drug delivery; Reduced Graphene Oxide.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:The authors indicate no potential conflicts of interest. Anandhavelu Sanmugam reports financial support was provided by Sri Venkateswara College of Engineering. Dr. Abdulrahman I. Almansour reports a relationship with King Saud University that includes funding grants.

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